A halogenated ether with anesthetic properties
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Isomer(s)
44218Enflurane
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Isoflurane

Item No. 23989

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane
CAS Number
26675-46-7
Synonyms
  • (±)-Isoflurane
Molecular Formula
C3H2ClF5O
Formula Weight
184.5
Purity
≥98%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: miscibleDMSO: miscibleEthanol: miscibleEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
FC(OC(Cl)C(F)(F)F)F
InChi Code
InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
InChi Key
PIWKPBJCKXDKJR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $75

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    Product Description

    Isoflurane is a halogenated ether with anesthetic properties.1 While the mechanism of isoflurane anesthesia is not fully understood, mice resistant to isoflurane anesthesia have an 86% decrease in gene expression for the GABAA receptor subunit β1 compared with isoflurane-sensitive mice, indicating that the GABAA receptor may be required for its anesthetic effect. In mice, isoflurane (1.5% for 4 hours) impairs spatial recognition memory in the spontaneous alternation test and Y-maze and increases levels of phosphorylated Jnk1/2 for at least 24 hours.2 Formulations containing isoflurane have been used as anesthetics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X., Song, Z.G., Huang, D.X., et al. A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice. Genet. Mol. Res. 15(2), gmr.15027340 (2016).

    2. Jiang, S., Miao, B., and Chen, Y. Prolonged duration of isoflurane anesthesia impairs spatial recognition memory through the activation of JNK1/2 in the hippocampus of mice. Neuroreport 28(7), 386-390 (2017).