A vasoconstrictor
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Levonordefrin

Item No. 23993

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1R,2S)-2-amino-1-hydroxypropyl]-1,2-benzenediol
CAS Number
829-74-3
Synonyms
  • Corbadrine
  • (–)-α-methyl Noradrenaline
  • (–)-3,4-dihydroxy Norephedrine
Molecular Formula
C9H13NO3
Formula Weight
183.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
OC1=C(O)C=CC([C@@H](O)[C@@H](N)C)=C1
InChi Code
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
InChi Key
GEFQWZLICWMTKF-CDUCUWFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $69

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    50 mg

    $198

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    100 mg

    $363

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    Product Description

    Levonordefrin is the (–)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Item No. 16673), that acts as a vasoconstrictor.1 Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer.2 It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine (Item No. 23402) and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%.3 Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Larson, P.O. Vasoconstrictors: Chemistry, mode of action, and dosage. Anesthesia and Analgesia in Dermatologic Surgery 42, 29-60 (2008).

    2. Luduena, F.P., Hoppe, J.O., Oyen, I.H., et al. Some pharmacologic properties of levo- and dextro-nordefrin. J. Dent. Res. 37(2), 206-213 (1958).

    3. Simone, J.L., Tortamano, N., Armonia, P.L., et al. Cardiovascular alterations caused by the administration of 2% mepivacaine HCl with 1:20,000 levonordefrin (Carbocain®) in dogs. Braz. Dent. J. 8(2), 85-90 (1997).