An inhibitor of tyrosine hydroxylase
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Metyrosine

Item No. 24001

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-L-tyrosine
CAS Number
672-87-7
Synonyms
  • α-Methyl-L-p-tyrosine
  • MK-781
  • L-α-MT
Molecular Formula
C10H13NO3
Formula Weight
195.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: <50 µg/mlDMSO: <50 µg/mlEthanol: <50 µg/mlPBS (pH 7.2): >2 mg/ml
SMILES
OC1=CC=C(C[C@](N)(C)C(O)=O)C=C1
InChi Code
InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m1/s1
InChi Key
NHTGHBARYWONDQ-SNVBAGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $54

    Add

    100 mg

    $102

    Add

    250 mg

    $238

    Add

    500 mg

    $444

    Add
    Product Description

    Metyrosine is an inhibitor of tyrosine hydroxylase.1 In vivo, metyrosine (200 mg/kg) reduces norepinephrine and dopamine levels in rat brain and disrupts conditioned avoidance behavior in a dose-dependent manner. Metyrosine reduces dopamine transporter knockdown-induced hyperactivity and rearing behavior and increases exploratory behavior in a hole board assay in a mouse model of bipolar disorder mania.2 It reduces hypertension induced by dexamethasone (Item No. 11015) and cyclosporin in rats.3,4 Metyrosine also inhibits norepinephrine production and increases plasma levels of leptin in fasted and fed mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moore, K.E., Wright, P.F., and Bert, J.K. Toxicologic studies with α-methyltyrosine, an inhibitor of tyrosine hydroxylase. J. Pharm. Exp. Ther. 155(3), 506-515 (1967).

    2. van Enkhuizen, J., Geyer, M.A., Halberstadt, A.L., et al. Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder. J. Affect. Disord. 155, 247-254 (2014).

    3. Soto-Pina, A.E., Franklin, C., Rani, C.S.S., et al. A novel model of dexamethasone-induced hypertension: Use in investigating the role of tyrosine hydroxylase. J. Pharmacol. Exp. Ther. 358(3), 528-536 (2016).

    4. Shimizu, H., Kumai, T., and Kobayashi, S. Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension. Jpn. J. Pharmacol. 85(3), 306-312 (2001).

    5. Rayner, D.V., Simon, E., Duncan, J.S., et al. Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor a-methyl-p-tyrosine. FEBS Lett. 429(3), 395-398 (1998).