A histamine H1 receptor antagonist
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Acrivastine

Item No. 24021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-[6-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-2-pyridinyl]-2-propenoic acid
CAS Number
87848-99-5
Synonyms
  • BW 0270C
  • BW A825C
Molecular Formula
C22H24N2O2
Formula Weight
348.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
CC1=CC=C(/C(C2=NC(/C=C/C(O)=O)=CC=C2)=C\CN3CCCC3)C=C1
InChi Code
InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
InChi Key
PWACSDKDOHSSQD-IUTFFREVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $43

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    10 mg

    $81

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    25 mg

    $190

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    50 mg

    $313

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    Product Description

    Acrivastine is a histamine H1 receptor antagonist with a Ki value of 10 nM in COS-7 cells expressing the human receptor.1 In vivo, acrivastine (1 mg/kg) completely inhibits response to histamine in guinea pigs.2 Formulations containing acrivastine have been used for the treatment of seasonal allergies and hay fever.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wieland, K., Laak, A.M., Smit, M.J., et al. Mutational analysis of the antagonist-binding site of the histamine H1 receptor. The Journal of Biological Chemisty 274(42), 29994-30000 (1999).

    2. Hoshiko, K., Chapman, I.D., and Morley, J. Histamine(H1) antagonists and airway hyperreactivity in the guinea-pig. Agents Actions Suppl. 34, 323-333 (1991).