Acephate

Acephate is an organophosphate insecticide that is active against a variety of insects.¹ It inhibits acetylcholinesterase in the house fly with a topical 24-hour LD₅₀ value of 1.8 µg/g but has millimolar IC₅₀ values for vertebrate cholinesterases.^2,3 In rats, acephate (140 mg/kg) induces reversible hyperglycemia after two and six hours and increases plasma corticosterone, liver glucose-6-phosphate, and liver tyrosine aminotransferase.¹ It also increases liver glycogen levels by 3.5-fold after six hours. Formulations containing acephate have been used in the control of insects in agriculture and horticulture.

WARNING This product is not for human or veterinary use.

1. Joshi, A.K.R., and Rajini, P.S. Reversible hyperglycemia in rats following acute exposure to acephate, an organophosphorus insecticide: Role of gluconeogenesis. Toxicology 257(1-2), 40-45 (2009).

2. Rojakovick, A.S., and March, R.B. In vitro and in vivo inhibition of house fly acetylcholinesterase by the N-acetyl phosphoramidothioate orthene. J. Econ. Entomol. 65(5), 1505-1507 (1972).

3. Hussain, M.A., Mohamad, R.B., and Oloffs, P.C. Studies on the toxicity, metabolism, and anticholinesterase properties of acephate and methamidophos. J. Environ. Sci. Health B 20(1), 129-147 (1985).