A mixture of alkaloids with diverse biological activities
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Ergoloid (mesylates)

Item No. 24095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dihydro-ergotoxine, monomethanesulfonate
CAS Number
8067-24-1
Molecular Formula
C134H184N20O32S4
Formula Weight
2715.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: 1 mg/ml
SMILES
[H][C@@]12[C@](C3=C4C(C2)=CNC4=CC=C3)([H])C[C@@H](C(N[C@@]5(C(C)C)C(N([C@@H](C(C)C)C(N6[C@@]7([H])CCC6)=O)[C@@]7(O)O5)=O)=O)CN1C.[H][C@@]89[C@](C%10=C%11C(C9)=CNC%11=CC=C%10)([H])C[C@@H](C(N[C@@]%12(C(C)C)C(N([C@@H](CC%13=CC=CC=C%13)C(N%14[C@@]%15([H])CCC%14)=O)[C@@]%15(O)O%12)=O)=O)CN8C.[H][C@@]%16%17[C@](C%18=C%19C(C%17)=CNC%19=CC=C%18)([H])C[C@@H](C(N[C@@]%20(C(C)C)C(N([C@@H](CC(C)C)C(N%21[C@@]%22([H])CCC%21)=O)[C@@]%22(O)O%20)=O)=O)CN%16C.[H][C@@]%23%24[C@](C%25=C%26C(C%24)=CNC%26=CC=C%25)([H])C[C@@H](C(N[C@@]%27(C(C)C)C(N([C@]([C@](C)([H])CC)([H])C(N%28[C@@]%29([H])CCC%28)=O)[C@@]%29(O)O%27)=O)=O)CN%23C.OS(C)(=O)=O.OS(C)(=O)=O.OS(C)(=O)=O.OS(C)(=O)=O
InChi Code
InChI=1S/C35H41N5O5.2C32H43N5O5.C31H41N5O5.4CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20;1-6-18(4)27-29(39)36-12-8-11-25(36)32(41)37(27)30(40)31(42-32,17(2)3)34-28(38)20-13-22-21-9-7-10-23-26(21)19(15-33-23)14-24(22)35(5)16-20;1-16(2)26-28(38)35-11-
InChi Key
PBKVEOSEPXMKDN-HJMQKNHVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $41

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    50 mg

    $72

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    100 mg

    $127

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    Product Description

    Ergoloid is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine.1 It blocks reflex vasodilation and vasoconstriction induced by norepinephrine (Item No. 16673) in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner.2 It also acts as an erectogenic agent in rats.3 Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsushita, S., Ying, L.H., Kaneko, J., et al. Pharmacological studies on reflex renal vasodilatation. Tohoku J. Exp. Med. 99(1), 51-57 (1969).

    2. Markstein, R., and Wagner, H. The effect of dihydroergotoxin, phentolamine and pindolol on catecholamine-stimulated adenylcyclase in rat cerebral cortex. FEBS Lett. 55(1), 275-277 (1975).

    3. Radosavljevic, M., Pajovic, B., Radunovic, M., et al. Influence of dihydroergotoxine, bromocriptine, and ergotamine on penile erection in Wistar rats. J. Androl. 33(5), 866-871 (2012).