An insecticide
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Buprofezin

Item No. 24137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1,1-dimethylethyl)imino]tetrahydro-3-(1-methylethyl)-5-phenyl-4H-1,3,5-thiadiazin-4-one
CAS Number
69327-76-0
Synonyms
  • NNI-750
Molecular Formula
C16H23N3OS
Formula Weight
305.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C1N(C(C)C)/C(SCN1C2=CC=CC=C2)=N/C(C)(C)C
InChi Code
InChI=1S/C16H23N3OS/c1-12(2)19-14(17-16(3,4)5)21-11-18(15(19)20)13-9-7-6-8-10-13/h6-10,12H,11H2,1-5H3/b17-14-
InChi Key
PRLVTUNWOQKEAI-VKAVYKQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Buprofezin is an insecticide that acts by inhibiting chitin synthesis.1 It inhibits chitin synthesis by 35% in N. lugens nymphs when used at a concentration of 10 ppm. Buprofezin (500 ppm) decreases the lifespan of adult T. vaporariorum with 17.9% mortality after 24 hours.2 It inhibits mitochondrial respiration when used at concentrations of 10 and 30 µM, reduces the expression of enzymes involved in the tricarboxylic acid (TCA) cycle, and stimulates glycolysis in HepG2 cells.3 It also dose-dependently increases the production of reactive oxygen species (ROS) in vitro. Buprofezin accumulates in mouse liver following oral administration of doses ranging from 46.3 to 417 mg/kg. It is not mutagenic and has LD50 values of 6,810 and 5,010 mg/kg in male and female rats, respectively.4 Formulations containing buprofezin have been used as insecticides.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Izawa, Y., Uchida, M., Sugimoto, T., et al. Inhibition of chitin biosynthesis by buprofezin analogs in relation to their activity controlling Nilaparvata lugens Stål. Pest. Biochem. Phys. 24(3), 343-347 (1985).

    2. Yasui, M., Fukada, M., and Maekawa, S. Effects of buprofezin on different developmental stages of the greenhouse whitefly, Trialeurodes vaporariorum (WESTWOOD) (Homoptera : Aleyrodidae). Appl. Ent. Zool. 20(3), 340-347 (1985).

    3. Ji, X., Ku, T., Zhu, N., et al. Potential hepatic toxicity of buprofezin at sublethal concentrations: ROS-mediated conversion of energy metabolism. J. Hazard. Mater. 320, 176-186 (2016).

    4. Xiao, H., Yang, Y., Tang, L., et al. Observation of toxicity and mutagenesis of insect growth regulator buprofezin. Nanj. Yixuey. Xue. 12(1), 23-26 (1992).