A neuroprotective peptide
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Humanin (human) (trifluoroacetate salt)

Item No. 24150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-L-alanine, trifluoroacetate salt
Synonyms
  • HN
Molecular Formula
C119H204N34O32S2 • XCF3COOH
Formula Weight
2687.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CS)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)C)=O)CCSC.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C119H204N34O32S2.C2HF3O2/c1-19-65(14)92(112(180)144-81(54-90(160)161)104(172)145-82(52-63(10)11)115(183)153-46-29-37-87(153)110(178)149-91(64(12)13)111(179)139-72(32-23-24-41-120)97(165)136-74(35-27-44-130-119(126)127)98(166)135-73(34-26-43-129-118(124)125)96(164)133-67(16)116(184)185)150-99(167)75(38-39-89(158)159)137-106(174)84(57-155)147-113(181)93(68(17)156)151-105(173)79(51-62(8)9)142-101(169)77(49-60(4)5)140-100(168)76(48-59(2)3)141-102(170)78(50-61(6)7)143-108(176)85(58-186)148-107(175)83(56-154)146-103(171)80(53-69-30-21-20-22-31-69)134-88(157)55-131-95(163)71(33-25-42-128-117(122)123)138-109(177)86-36-28-45-152(86)114(182)66(15)132-94(162)70(121)40-47-187-18;3-2(4,5)1(6)7/h20-22,30-31,59-68,70-87,91-93,154-156,186H,19,23-29,32-58,120-121H2,1-18H3,(H,131,163)(H,132,162)(H,133,164)(H,134,157)(H,135,166)(H,136,165)(H,137,174)(H,138,177)(H,139,179)(H,140,168)(H,141,170)(H,142,169)(H,143,176)(H,144,180)(H,145,172)(H,146,171)(H,147,181)(H,148,175)(H,149,178)(H,150,167)(H,151,173)(H,158,159)(H,160,161)(H,184,185)(H4,122,123,128)(H4,124,125,129)(H4,126,127,130);(H,6,7)/t65-,66-,67-,68+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,91-,92-,93-;/m0./s1
InChi Key
GOECCOZLWZRFBQ-XGXJXVHNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Humanin is a neuroprotective peptide.1 It completely blocks amyloid-β (1-42) (Aβ42) and Aβ43-induced cell death of primary cortical neurons when used at a concentration of 10 μM. Humanin also prevents amyloid precursor protein (APP) antibody-induced cell death and reduces neurotoxicity in FH11 cells induced by the APP mutants A617G-APP, L648P-APP, V642I-APP, and NL-APP, which are associated with familial Alzheimer's disease (IC50s = 0.1-1 μM). In vivo, humanin (0.375 mg/kg per hour) increases systemic insulin sensitivity and enhances glucose uptake in skeletal muscle of rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hashimoto, Y., Niikura, T., Ito, Y., et al. Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer’s disease-relevant insults. J. Neurosci. 21(23), 9235-9245 (2001).

    2. Muzumdar, R.H., Huffman, D.M., Atzmon, G., et al. Humanin: A novel central regulator of peripheral insulin action. PLoS One 4(7), e6334 (2009).