A macrolide antibiotic
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Isomer(s)
41972Desmycosin
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Leucomycin A5

Item No. 24177

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4B-butanoate leucomycin V
CAS Number
18361-45-0
Synonyms
  • Kitasamycin A5
  • Leukomycin A5
  • Turimycin H4
Molecular Formula
C39H65NO14
Formula Weight
771.9
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
λmax
232 nm
SMILES
O=C1C[C@H]([C@@H]([C@H]([C@H](C[C@H]([C@H](/C=C/C=C/C[C@H](O1)C)O)C)CC=O)O[C@@]2(O[C@@H]([C@H]([C@@H]([C@H]2O)N(C)C)O[C@]3(C[C@@](O)([C@H]([C@@H](O3)C)OC(CCC)=O)C)[H])C)[H])OC)O
InChi Code
InChI=1S/C39H65NO14/c1-10-14-29(44)52-37-25(5)50-31(21-39(37,6)47)53-34-24(4)51-38(33(46)32(34)40(7)8)54-35-26(17-18-41)19-22(2)27(42)16-13-11-12-15-23(3)49-30(45)20-28(43)36(35)48-9/h11-13,16,18,22-28,31-38,42-43,46-47H,10,14-15,17,19-21H2,1-9H3/b12-11+,16-13+/t22-,23-,24-,25+,26+,27+,28-,31+,32-,33-,34-,35+,36+,37+,38+,39-/m1/s1
InChi Key
JZVYPSLDMXOITF-MJRCUCNNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Leucomycin A5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis.1,2 It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimurium, or E. coli with MICs ranging from 5 to >10 µg/ml.1 Leucomycin A5 is also active against penicillin-susceptible and -resistant S. pyogenes (MICs = 0.8 and 3.2 µg/ml, respectively) and S. faecalis (MIC = 0.8 µg/ml).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Omura, S., Katagiri, M., Umezawa, I., et al. Structure-biological activities relationships among the leucomycins and their derivatives. J. Antibiot. (Tokyo) 21(9), 532-538 (1968).

    2. Ishii, T., Hida, T., Iinuma, S., et al. TAN-1323 C and D, new concanamycin-group antibiotics; detection of the angiostatic activity with a wide range of macrolide antibiotics. J. Antibiot. (Tokyo) 48(1), 12-20 (1995).

    3. Singh, K., and Rakhit, S. Microbial transformation of leucomycin A5. J. Antibiot. (Tokyo) 32(1), 78-80 (1979).