An inhibitor of EGFR
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Signaling
Growth Factor Receptors

Arry-380 analog

Item No. 24186

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine
CAS Number
937265-83-3
Molecular Formula
C29H27N7O4S
Formula Weight
569.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
λmax
334, 361 nm
SMILES
CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC4=C(C=C(C5=CC=C(CNCCS(C)(=O)=O)O5)C=C6)C6=NC=N4)=C1
InChi Code
InChI=1S/C29H27N7O4S/c1-19-13-21(4-7-26(19)39-22-9-11-36-28(15-22)32-18-34-36)35-29-24-14-20(3-6-25(24)31-17-33-29)27-8-5-23(40-27)16-30-10-12-41(2,37)38/h3-9,11,13-15,17-18,30H,10,12,16H2,1-2H3,(H,31,33,35)
InChi Key
QVMNYGOVNWWFKF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $135

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    10 mg

    $169

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    25 mg

    $336

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    Product Description

    Arry-380 analog was designed as an inhibitor of EGFR (ErbB1).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lyssikatos, J.P., Hicks, J.M., Marmsater, F.P., et al. N4-phenyl-quinazoline-4-amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases. (2017).