Chlorotoluron

Chlorotoluron is a phenylurea herbicide.¹ It is genotoxic, inducing the formation of chromosome aberrations and sister chromatid exchange (SCE) in CHEL liver epithelial cells in a concentration-dependent manner.² Chlorotoluron (625-5,000 mg/kg) induces testicular anaplasia as well as looseness and incrassation to the basement membrane that destroys the blood-testis barrier, increases superoxide dismutase (SOD) activity, and degrades testis mitochondria in mice.³ It reduces food intake and body weight and induces hemolytic anemia, hemosiderosis of the spleen, and brown atrophy in dogs when administered at a dose of 9,200 ppm in the diet.⁴

WARNING This product is not for human or veterinary use.

1. Banyiova, K., Cup, P., and Kohoutek, J. An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron. Environ. Sci. Pollut. Res. Int. 22(14), 10713-10720 (2015).

2. Federico, C., Motta, S., Palmieri, C., et al. Phenylurea herbicides induce cytogenetic effects in Chinese hamster cell lines. Mutat. Res. 721(1), 89-94 (2011).

3. Mu, H., Zhang, P., and Xu, J. Testicular toxicity and mechanisms of chlorotoluron compounds in the mouse. Toxicol. Mech. Methods 17(8), 483-488 (2007).

4. Zak, F., and Sachsse, K. Oral toxicity of the herbibide chlortoluron [N-(3-chloro-4-methylphenyl)-N,N'-dimethylurea] in rats and dogs. Proc. Eur. Soc. Study Drug Tox. 12, 272-281 (1971).