Diniconazole

Diniconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.¹ It is fungicidal against B. cinerea, S. fimicola, F. graminearum, S. cepivorum, and B. sorokiniana (EC₅₀s = 0.012, <0.001, 0.008, 0.02, and 0.06 mg/l, respectively).² Diniconazole acts as a plant growth regulator, decreasing height and leaf area in bean plants when applied to roots at a concentration of 5 mg/l. It exhibits dose-dependent toxicity in zebrafish.³

WARNING This product is not for human or veterinary use.

1. Yoshida, Y., Aoyama, Y., Takano, H., et al. Stereo-selective interaction of enantiomers of diniconazole, a fungicide, with purified P-450/14DM from yeast. Biochem. Biophys. Res. Commun. 137(1), 513-519 (1986).

2. Fletcher, R.A., Hofstra, G., and Gao, J. Comparative fungitoxic and plant growth regulating properties of triazole derivatives. Plant Cell Physiol. 27(2), 367–371 (1986).

3. Jing, G., Wen-hua, S., Feng, D., et al. Acute toxicity study on zebrafish (Danio rerio) exposure to triazole fungicides. J. SE Univ. (Med. Sci. Ed.) 29(4), 402-406 (2010).