A biotin-conjugated pan-caspase inhibitor
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Biotin-VAD-FMK

Item No. 24305

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
methyl (3S,6S,9S)-3-(2-fluoroacetyl)-9-isopropyl-6-methyl-5,8,11,18-tetraoxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10,17-tetraazadocosanoate
CAS Number
1135688-15-1
Molecular Formula
C30H49FN6O8S
Formula Weight
672.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mM
SMILES
O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)CCCCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O
InChi Code
InChI=1S/C30H49FN6O8S/c1-17(2)26(29(43)33-18(3)28(42)34-19(21(38)15-31)14-25(41)45-4)36-24(40)12-6-5-9-13-32-23(39)11-8-7-10-22-27-20(16-46-22)35-30(44)37-27/h17-20,22,26-27H,5-16H2,1-4H3,(H,32,39)(H,33,43)(H,34,42)(H,36,40)(H2,35,37,44)/t18-,19-,20-,22-,26-,27-/m0/s1
InChi Key
MOQLQMKJGYKHCT-VRKQFSAKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $477

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    Product Description

    Biotin-VAD-FMK is a biotin-conjugated form of the cell-permeable caspase inhibitor Z-VAD(OMe)-FMK (Item No. 14463).1 It is an affinity probe that allows for detection and immobilization of caspases using the biotin ligand. Biotin-VAD-FMK inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-α and ActD. It also binds to caspase-3 and caspase-8 in hepatocyte lysates, an effect that can be blocked by the caspase inhibitor Ac-DEVD-CHO (Item No. 10017).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, J., Bombeck, C.A., Yang, S., et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. The Journal of Biological Chemisty 274(24), 17325-17333 (1999).