A CaMKII inhibitor
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Calmodulin-Dependent Protein Kinase II (290-309) (trifluoroacetate salt)

Item No. 24318

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-threonyl-L-threonyl-L-methionyl-L-leucyl-L-alanine, trifluoroacetate salt
Molecular Formula
C103H185N31O24S • XCF3COOH
Formula Weight
2273.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)C)=O)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC1=CC=CC=C1)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C103H185N31O24S.C2HF3O2/c1-17-58(10)80(98(154)131-75(50-57(8)9)97(153)133-82(63(15)136)100(156)134-81(62(14)135)99(155)126-72(39-46-159-16)92(148)127-73(48-55(4)5)93(149)119-61(13)101(157)158)132-84(140)59(11)117-79(138)53-116-86(142)66(33-21-25-40-104)122-95(151)74(49-56(6)7)128-90(146)68(35-23-27-42-106)124-89(145)71(38-30-45-115-103(112)113)125-88(144)70(37-29-44-114-102(110)111)120-83(139)60(12)118-94(150)77(52-78(109)137)130-96(152)76(51-64-31-19-18-20-32-64)129-91(147)69(36-24-28-43-107)123-87(143)67(34-22-26-41-105)121-85(141)65(108)47-54(2)3;3-2(4,5)1(6)7/h18-20,31-32,54-63,65-77,80-82,135-136H,17,21-30,33-53,104-108H2,1-16H3,(H2,109,137)(H,116,142)(H,117,138)(H,118,150)(H,119,149)(H,120,139)(H,121,141)(H,122,151)(H,123,143)(H,124,145)(H,125,144)(H,126,155)(H,127,148)(H,128,146)(H,129,147)(H,130,152)(H,131,154)(H,132,140)(H,133,153)(H,134,156)(H,157,158)(H4,110,111,114)(H4,112,113,115);(H,6,7)/t58-,59-,60-,61-,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,80-,81-,82-;/m0./s1
InChi Key
MCESTELTQHVODK-LTFBEUFTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $267

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    Product Description

    Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain.1,2 It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 52 nM and CaMKII-dependent phosphodiesterase activity (IC50 = 1.1 nM). Calmodulin-dependent protein kinase II (290-309) has been used in the study of CaM binding, autophosphorylation, and dynamics.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Payne, E.M., Fong, Y.-L., Ono, T., et al. Calcium/Calmodulin-dependent Protein Kinase II. The Journal of Biological Chemisty 263(15), 7190-7195 (1988).

    2. Lin, C.R., Kapiloff, M.S., Durgerian, S., et al. Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proc. Natl. Acad. Sci. USA 84(16), 5962-5966 (1987).

    3. Wyttenbach, T., Grabenauer, M., Thalassinos, K., et al. The effect of calcium ions and peptide ligands on the relative stabilities of the calmodulin dumbbell and compact structures. J. Phys. Chem. B. 114(1), 437-447 (2010).

    4. Colbran, R.J., and Soderling, T.R. Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptides. The Journal of Biological Chemisty 265(19), 11213-11219 (1990).