A phospholipid
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Phosphatidic Acids (ammonium salt)

Item No. 24344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C39H72O8P • NH4 (for oleoyl)
Formula Weight
718.0
Purity
≥98%
Formulation (Request formulation change)
A solution in chloroform
Solubility(Learn about Variance in Solubility)
Chloroform: solubleEther: soluble
SMILES
OP(OC[C@H](OC([R])=O)COC([R])=O)([O-])=O.[NH4+]
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $118

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    50 mg

    $208

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
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    Product Description

    Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.1 It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others.2,3 It has roles in shaping cellular membranes, cellular signaling, vesicle fission and fusion, as well as mitochondrial division and fusion. It stimulates respiratory burst in neutrophils independent of diacylglycerol and activates monoacylglycerol acyltransferase, phospholipase C (PLC), Ras, and phosphatidylinositol 4-phosphate (PIP4) kinase in several cell lines. This product contains phosphatidic acid molecular species with primarily C16:0 and C18:1 fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1053]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Athenstaedt, K., and Daum, G. Phosphatidic acid, a key intermediate in lipid metabolism. Eur. J. Biochem. 266(1), 1-16 (1999).

    2. Járai, Z., Wagner, J.A., Goparaju, S.K., et al. Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice. Hypertension 35, 679-684 (2000).

    3. Kameoka, S., Adachi, Y., Okamoto, K., et al. Phosphatidic acid and cardiolipin coordinate mitochondrial dynamics. Trends Cell Biol. 28(1), 67-76 (2018).