An internal standard for the quantification of C18 ceramide
Related Products
Alternative(s)
22788C18 Ceramide-d7 (d18:1-d7/18:0)
Unlabeled Version(s)
19556C18 Ceramide (d18:1/18:0)
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C18 Ceramide-d3 (d18:1/18:0-d3)

Item No. 24396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-d3]-octadecanamide
CAS Number
2011762-82-4
Synonyms
  • C18 Ceramide-d3
  • Cer(d18:1/18:0)-d3
  • Ceramide-d3 (d18:1/18:0-d3)
Molecular Formula
C36H68D3NO3
Formula Weight
569.0
Purity
≥99% deuterated forms (d1-d3); ≤1% d0
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleDMF: SolubleEthanol: Warmed
SMILES
OC[C@H](NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC
InChi Code
InChI=1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1/i1D3
InChi Key
VODZWWMEJITOND-MOZMBTNASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $469

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    Product Description

    C18 Ceramide-d3 (d18:1/18:0) is intended for use as an internal standard for the quantification of C18 Ceramide (d18:1/18:0) (Item No. 19556) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.1 Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.2 It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.3 [Matreya, LLC. Catalog No. 2201]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizutani, Y., Kihara, A., and Igarashi, Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 390(Pt. 1), 263-271 (2005).

    2. Koybasi, S., Senkal, C.E., Sundararaj, K., et al. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. The Journal of Biological Chemisty 279(43), 44311-44319 (2004).

    3. Bergman, B.C., Brozinick, J.T., Strauss, A., et al. Muscle sphingolipids during rest and exercise: A C18:0 signature for insulin resistance in humans. Diabetologia 59(3), 785-791 (2016).

    Product Citations

    Hällqvist, J., Toomey, C.E., Pinto, R., et al. Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson’s disease brain. Nat. Commun. 16(1), 10490 (2025).