A peptide hormone that lowers blood calcium levels
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Alternative(s)
31487Calcitonin (eel)
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Calcitonin (human) (trifluoroacetate salt)

Item No. 24409

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-cysteinylglycyl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-methionyl-L-leucylglycyl-L-threonyl-L-tyrosyl-L-threonyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-threonyl-L-phenylalanyl-L-prolyl-L-glutaminyl-L-threonyl-L-alanyl-L-isoleucylglycyl-L-valylglycyl-L-alanyl-L-prolinamide, cyclic (1→7)-disulfide, trifluoroacetate salt
Synonyms
  • Ba 47175
  • Calcitonin (1-32) (human)
  • hCT
  • Thyrocalcitonin (human)
Molecular Formula
C151H226N40O45S3 • XCF3COOH
Formula Weight
3417.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H](C(C)C)NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@@H]2CCCN2C([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC(CNC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N3)CSSC[C@H](N[H])C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)CC(O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)CC6=CC=CC=C6)=O)CC7=CN=CN7)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C151H226N40O45S3.C2HF3O2/c1-17-75(8)118(144(229)163-67-114(205)183-117(74(6)7)143(228)162-64-112(203)165-77(10)150(235)190-50-29-38-106(190)124(158)209)185-125(210)76(9)166-145(230)120(79(12)194)186-131(216)92(45-47-109(155)200)170-142(227)107-39-30-51-191(107)151(236)103(58-85-35-25-20-26-36-85)180-148(233)122(81(14)196)188-139(224)99(59-87-63-159-71-164-87)176-133(218)96(55-83-31-21-18-22-32-83)174-128(213)90(37-27-28-49-152)168-136(221)101(61-111(157)202)177-134(219)97(56-84-33-23-19-24-34-84)175-137(222)102(62-116(207)208)178-129(214)91(44-46-108(154)199)171-147(232)121(80(13)195)187-138(223)98(57-86-40-42-88(198)43-41-86)179-146(231)119(78(11)193)184-115(206)66-161-127(212)94(53-72(2)3)172-130(215)93(48-52-237-16)169-141(226)105-70-239-238-69-89(153)126(211)160-65-113(204)167-100(60-110(156)201)135(220)173-95(54-73(4)5)132(217)181-104(68-192)140(225)189-123(82(15)197)149(234)182-105;3-2(4,5)1(6)7/h18-26,31-36,40-43,63,71-82,89-107,117-123,192-198H,17,27-30,37-39,44-62,64-70,152-153H2,1-16H3,(H2,154,199)(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,209)(H,159,164)(H,160,211)(H,161,212)(H,162,228)(H,163,229)(H,165,203)(H,166,230)(H,167,204)(H,168,221)(H,169,226)(H,170,227)(H,171,232)(H,172,215)(H,173,220)(H,174,213)(H,175,222)(H,176,218)(H,177,219)(H,178,214)(H,179,231)(H,180,233)(H,181,217)(H,182,234)(H,183,205)(H,184,206)(H,185,210)(H,186,216)(H,187,223)(H,188,224)(H,189,225)(H,207,208);(H,6,7)/t75-,76-,77-,78+,79+,80+,81+,82+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,117-,118-,119-,120-,121-,122-,123-;/m0./s1
InChi Key
VMLYVDPACCCWRD-LJYBWBPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Calcitonin is a peptide hormone that lowers blood calcium levels and inhibits bone resorption.1 It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin gene-related peptide (Item No. 24405), and adrenomedullin.2 The binding of human calcitonin to the calcitonin receptor (CTR) is modulated by receptor activity-modifying proteins (RAMPs).3 Calcitonin binds to CTR2 with IC50 values of 8.5, 6.2, 10.7, and 5.8 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in rabbit aortic endothelial cells (RAECs) expressing CTR2 alone, or co-transfected with RAMP1, 2, or 3 (EC50s = 0.07, 0.08, 0.05, and 0.99 nM, respectively). In a bone resorption assay, human calcitonin inhibits pit formation in dentine by human giant cell tumor (GCT) cells, rabbit osteoclasts, and mouse osteoclasts (ID50s = 0.19, 0.032, and 0.21 nM, respectively).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Foster, G.V. Calcitonin. A review of experimental and clinical investigations. Postgrad. Med. J. 44(511), 411-422 (1968).

    2. Wimalawansa, S.J. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: A peptide superfamily. Crit. Rev. Neurobiol. 11(2-3), 167-239 (1997).

    3. Muff, R., Bühlmann, N., Fischer, J.A., et al. An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3. Endocrinology 140(6), 2924-2927 (1999).

    4. Lida, S., Kakudo, S., Mori, Y., et al. Human calcitonin has the same inhibitory effect on osteoclastic bone resorption by human giant cell tumor cells as salmon calcitonin. Calcif. Tissue Int. 59(2), 100-104 (1996).