A peptide hormone
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Calcitonin (eel)

Item No. 31487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
26-L-aspartic acid-27-L-valine-29-L-alanine-calcitonin (salmon)
CAS Number
57014-02-5
Synonyms
  • eCT
  • Elcatonin
  • H-CSNLSTCVLGKLSQELHKLQTYPRTDVGAGTP-NH2
  • H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2
Molecular Formula
C146H241N43O47S2
Formula Weight
3414.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
SMILES
NC([C@@H]1CCCN1C([C@@]([C@H](O)C)([H])NC(CNC([C@@H](NC(CNC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@@]([C@H](O)C)([H])NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@H](CC3=CC=C(O)C=C3)NC([C@@]([C@H](O)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCCCN[H])NC([C@H](CC4=CNC=N4)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@@H](NC([C@H](CCCCN[H])NC(CNC([C@@H](NC([C@H](C(C)C)NC([C@H]5NC([C@@]([C@H](O)C)([H])NC([C@H](CO)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CSSC5)N[H])=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O
InChi Code
InChI=1S/C146H241N43O47S2/c1-66(2)47-88(175-140(231)112(72(13)14)184-137(228)100-64-238-237-63-81(149)119(210)178-97(60-190)135(226)174-94(54-105(152)200)132(223)172-92(51-70(9)10)130(221)180-99(62-192)136(227)187-115(76(18)195)143(234)181-100)120(211)159-58-107(202)163-82(27-20-22-42-147)121(212)169-91(50-69(7)8)129(220)179-98(61-191)134(225)167-85(36-39-103(150)198)123(214)165-87(38-41-109(204)205)124(215)171-90(49-68(5)6)128(219)173-93(53-79-56-156-65-161-79)131(222)164-83(28-21-23-43-148)122(213)170-89(48-67(3)4)127(218)166-86(37-40-104(151)199)126(217)186-114(75(17)194)142(233)177-96(52-78-32-34-80(197)35-33-78)144(235)189-46-26-31-102(189)138(229)168-84(29-24-44-157-146(154)155)125(216)185-113(74(16)193)141(232)176-95(55-110(206)207)133(224)183-111(71(11)12)139(230)160-57-106(201)162-73(15)118(209)158-59-108(203)182-116(77(19)196)145(236)188-45-25-30-101(188)117(153)208/h32-35,56,65-77,81-102,111-116,190-197H,20-31,36-55,57-64,147-149H2,1-19H3,(H2,150,198)(H2,151,199)(H2,152,200)(H2,153,208)(H,156,161)(H,158,209)(H,159,211)(H,160,230)(H,162,201)(H,163,202)(H,164,222)(H,165,214)(H,166,218)(H,167,225)(H,168,229)(H,169,212)(H,170,213)(H,171,215)(H,172,223)(H,173,219)(H,174,226)(H,175,231)(H,176,232)(H,177,233)(H,178,210)(H,179,220)(H,180,221)(H,181,234)(H,182,203)(H,183,224)(H,184,228)(H,185,216)(H,186,217)(H,187,227)(H,204,205)(H,206,207)(H4,154,155,157)/t73-,74+,75+,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-,113-,114-,115-,116-/m0/s1
InChi Key
JDJALSWDQPEHEJ-LMVCGNDWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Calcitonin is a 32-amino acid peptide hormone that lowers blood calcium levels and inhibits bone resorption.1,2 The amino acid sequence of eel calcitonin varies from salmon (Item No. 24410) and human (Item No. 24409) calcitonin at 3 and 16 positions, respectively.3 Calcitonin (eel) binds to calcitonin receptor 2 (CTR2) with higher affinity than human, porcine, or rat calcitonin (Kis = 0.01, 2.95, 0.44, and 5.89 nM, respectively, in radioligand binding assays). It inhibits gastric emptying in conscious dogs more potently than human calcitonin when administered at a dose of 10 µg/kg.3,4 Calcitonin (eel) increases the paw withdrawal threshold in a mouse model of carrageenan-induced inflammation when administered at a dose of 0.2 µg/paw.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Foster, G.V. Calcitonin. A review of experimental and clinical investigations. Postgrad. Med. J. 44(511), 411-422 (1968).

    2. Chesnut, C.H., III, Azria, M., Silverman, S., et al. Salmon calcitonin: A review of current and future therapeutic indications. Osteoporos. Int. 19(4), 479-491 (2008).

    3. Chen, W.-J., Armour, S., Way, J., et al. Expression cloning and receptor pharmacology of human calcitonin receptors from MCF-7 cells and their relationship to amylin receptors. Mol. Pharmacol. 52(6), 1164-1175 (1997).

    4. Nakamura, H., Asano, T., and Takeda, K. Gastrointestinal motor inhibition by exogenous human, salmon, and eel calcitonin in conscious dogs. Can. J. Physiol. Pharmacol. 73(1), 43-49 (1995).

    5. Guidobono, F., Netti, C., Villani, P., et al. Antinociceptive activity of eel calcitonin, injected into the inflamed paw in rats. Neuropharmacology 30(12A), 1275-1278 (1991).