An N-, P-, and Q-type calcium channel blocker
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ω-Conotoxin MVIIC (trifluoroacetate salt)

Item No. 24411

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-prolyl-L-cysteinyl-L-arginyl-L-lysyl-L-threonyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-serylglycyl-L-seryl-L-cysteinylglycyl-L-arginyl-L-arginylglycyl-L-lysyl-L-cysteinamide, cyclic (1→16),(8→20),(15→26)-tris(disulfide), 2,2,2-trifluoroacetate
Synonyms
  • SNX-230
Molecular Formula
C106H178N40O32S7 • XCF3COOH
Formula Weight
2749.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](N1)CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N[H])CSSC[C@H](N3)C(N[C@@H](CO)C(NCC4=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CSSC[C@H](NC([C@H](CO)N4)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C1=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)CC5=CC=C(O)C=C5)=O)CC(O)=O)=O)C3=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C106H178N40O32S7.C2HF3O2/c1-53-103(178)146-36-15-23-75(146)101(176)144-74-52-185-183-49-71-89(164)126-43-79(154)130-62(21-13-34-120-105(115)116)90(165)133-60(20-12-33-119-104(113)114)87(162)124-42-78(153)129-61(18-6-10-31-109)91(166)140-70(83(112)158)48-181-184-51-73(100(175)143-72(99(174)139-68(45-147)88(163)125-44-80(155)131-69(46-148)97(172)141-71)50-182-180-47-57(111)84(159)132-59(17-5-9-30-108)86(161)123-41-77(152)128-58(16-4-8-29-107)85(160)122-40-76(151)127-53)142-96(171)67(39-81(156)157)138-95(170)66(38-55-24-26-56(150)27-25-55)137-93(168)65(28-37-179-3)136-102(177)82(54(2)149)145-94(169)63(19-7-11-32-110)134-92(167)64(135-98(74)173)22-14-35-121-106(117)118;3-2(4,5)1(6)7/h24-27,53-54,57-75,82,147-150H,4-23,28-52,107-111H2,1-3H3,(H2,112,158)(H,122,160)(H,123,161)(H,124,162)(H,125,163)(H,126,164)(H,127,151)(H,128,152)(H,129,153)(H,130,154)(H,131,155)(H,132,159)(H,133,165)(H,134,167)(H,135,173)(H,136,177)(H,137,168)(H,138,170)(H,139,174)(H,140,166)(H,141,172)(H,142,171)(H,143,175)(H,144,176)(H,145,169)(H,156,157)(H4,113,114,119)(H4,115,116,120)(H4,117,118,121);(H,6,7)/t53-,54+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-;/m0./s1
InChi Key
DZZZBHOLPDYQSH-QHYFUXNNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $321

    Add

    500 µg

    $1,276

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. magus.1 It blocks N-type calcium channels on rat superior cervical ganglions (SCGs) and P-type calcium channels on rat Purkinje neurons (Kds = 30 and ~50 nM, respectively, in the presence of 5 mM barium).2 It also blocks Q-type channels in rat CA3 neurons. ω-Conotoxin MVIIC binds to rat brain membranes (IC50 = 0.3 nM) and completely blocks calcium uptake by rat brain synaptosomes when used at a concentration of 2.5 μM in the presence of 5 mM potassium.1 It blocks potassium-evoked dopamine (Item No. 21992) release from rat striatal slices (IC50 = ~128 nM) and potassium-evoked calcium-dependent glutamate release from rat brain synaptosomes.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hillyard, D.R., Monje, V.D., Mintz, I.M., et al. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9(1), 69-77 (1992).

    2. McDonough, S.I., Swartz, K.J., Mintz, I.M., et al. Inhibition of calcium channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J. Neurosci. 16(8), 2612-2623 (1996).

    3. Dobrev, D., and Andreas, K. Modulation of potassium-evoked [3H]dopamine release from rat striatal slices by voltage-activated calcium channel ligands: Effects of ω-conotoxin-MVIIC. Neurochem. Res. 22(9), 1085-1093 (1997).

    4. Turner, T.J., Lampe, R.A., and Dunlap, K. Characterization of presynaptic calcium channels with ω-conotoxin MVIIC and ω-grammotoxin SIA: Role for a resistant calcium channel type in neurosecretion. Mol. Pharmacol. 47(2), 348-353 (1995).