A tripeptide with diverse biological activities
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MSH Release-Inhibiting Factor (trifluoroacetate salt)

Item No. 24476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-prolyl-L-leucyl-glycinamide, trifluoroacetate salt
Synonyms
  • ​Melanocyte-stimulating Hormone Release-Inhibiting Factor
  • MIF-1
  • MSH-R-IF
Molecular Formula
C13H24N4O3 • XCF3COOH
Formula Weight
284.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C([C@@H](NC([C@H]1NCCC1)=O)CC(C)C)NCC(N)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C13H24N4O3.C2HF3O2/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9;3-2(4,5)1(6)7/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20);(H,6,7)/t9-,10-;/m0./s1
InChi Key
RNHWSCDHHHUWRY-IYPAPVHQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $90

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    25 mg

    $197

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    50 mg

    $349

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    100 mg

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    Product Description

    MSH release-inhibiting factor (MSH-R-IF) is a hypothalamic tripeptide that binds to rat striatum (Kd = 4.69 nM) and has diverse biological activities.1,2,3,4 In vivo, MSH-R-IF (0.1 mg/kg) decreases immobility of mice in the forced swim test, indicating antidepressant-like activity.2 MSH-R-IF (20 mg/kg) increases striatal concentration of dopamine (Item No. 21992) and the dopamine metabolites DOPAC, 3-methoxy tyramine (3-MT; Item No. 20511), and homovanillic acid (HVA) in a mouse model of Parkinson's disease induced by MPTP.3 It decreases vacuous chewing movements induced by haloperidol (Item No. 12014) in a rat model of tardive dyskinesia when administered at a dose of 2 mg/kg.4 MSH-R-IF also has anti-opiate effects, reversing analgesia induced by morphine (Item No. ISO60147) and an enkephalin in mice in a radiant heat tail-flick assay.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pan, W., and Kastin, A.J. From MIF-1 to endomorphin: The Tyr-MIF-1 family of peptides. Peptides 28(12), 2411-2434 (2007).

    2. Kastin, A.J., Abel, D.A., Ehrensing, R.H., et al. Tyr-MIF-1 and MIF-1 are active in the water wheel test for antidepressant drugs. Pharmacol. Biochem. Behav. 21(5), 767-771 (1984).

    3. Marcotte, E.R., Chugh, A., Mishra, R.K., et al. Protection against MPTP treatment by an analog of Pro-Leu-Gly-NH2 (PLG, MIF-1). Peptides 19(2), 403-406 (1998).

    4. Sharma, S., Paladino, P., Gabriele, J., et al. Pro-Leu-glycinamide and its peptidomimetic, PAOPA, attenuate haloperidol induced vacuous chewing movements in rat: A model of human tardive dyskinesia. Peptides 24(2), 313-319 (2003).