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SR-17018

Item No. 24480

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 5,6-dichloro Desmethylchlorphine
Technical Information
Formal Name
5,6-dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS Number
2134602-45-0
Molecular Formula
C19H18Cl3N3O
Formula Weight
410.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: slightly soluble
λmax
216, 302 nm
SMILES
ClC(C=C1)=CC=C1CN2CCC(N3C(NC4=C3C=C(Cl)C(Cl)=C4)=O)CC2
InChi Code
InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26)
InChi Key
LAGUDYUGRSQDKS-UHFFFAOYSA-N
Supplemental Data
Technical Brief (288KB .pdf)
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    SR-17018 (Item No. 24480) is an analytical reference standard categorized as an opioid.1 SR-17018 increases latency to withdraw in the hot plate and warm water tail-flick assay without inducing respiratory depression in mice, as well as induces place preference in a conditioned place preference test in mice.1,2 It also induces antinociceptive tolerance after repeated administration in mice.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, C.L., Kennedy, N.M., Ross, N.C., et al. Bias factor and therapeutic window correlate to predict safer opioid analgesics. Cell 171(5), 1165-1175 (2017).

    2. Kudla, L., Bugno, R., Podlewska, S., et al. Comparison of an addictive potential of μ-opioid receptor agonists with G protein bias: Behavioral and molecular modeling studies. Pharmaceutics 14(1), 55 (2021).