An Analytical Reference Standard
Related Products
Alternative(s)
24480SR-17018
Metabolite(s)
431705,6-dichloro nor-Orphine (hydrochloride)
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SR-17018 (hydrochloride)

Item No. 45831

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 5,6-dichloro Desmethylchlorphine
Technical Information
Formal Name
5,6-dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one, monohydrochloride
Molecular Formula
C19H18Cl3N3O • HCl
Formula Weight
447.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Sparingly soluble: 1-10 mg/ml
SMILES
ClC(C=C1)=CC=C1CN2CCC(N3C(NC4=C3C=C(Cl)C(Cl)=C4)=O)CC2.Cl
InChi Code
InChI=1S/C19H18Cl3N3O.ClH/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26;/h1-4,9-10,14H,5-8,11H2,(H,23,26);1H
InChi Key
ADTCPRNERWGYSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    SR-17018 (hydrochloride) (Item No. 45831) is an analytical reference standard categorized as an opioid.1 SR-17018 increases latency to withdrawal in the hot plate and warm water tail-flick assays without inducing respiratory depression in mice, as well as induces place preference in a conditioned place preference test in mice.1,2 It also induces antinociceptive tolerance after repeated administration in mice.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, C.L., Kennedy, N.M., Ross, N.C., et al. Bias factor and therapeutic window correlate to predict safer opioid analgesics. Cell 171(5), 1165-1175 (2017).

    2. Kudla, L., Bugno, R., Podlewska, S., et al. Comparison of an addictive potential of μ-opioid receptor agonists with G protein bias: Behavioral and molecular modeling studies. Pharmaceutics 14(1), 55 (2021).