A peptide hormone
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Obestatin (human) (trifluoroacetate salt)

Item No. 24552

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-phenylalanyl-L-asparaginyl-L-alanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-L-valylglycyl-L-isoleucyl-L-lysyl-L-leucyl-L-serylglycyl-L-valyl-L-glutaminyl-L-tyrosyl-L-glutaminyl-L-glutaminyl-L-histidyl-L-seryl-L-glutaminyl-L-alanyl-L-leucinamide, trifluoroacetate salt
Molecular Formula
C116H176N32O33 • XCF3COOH
Formula Weight
2546.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC(CNC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@H](CC(N)=O)NC([C@@H](N[H])CC2=CC=CC=C2)=O)=O)C)=O)=O)CC3=CC=CC=C3)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)C)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C116H176N32O33.C2HF3O2/c1-13-61(10)95(146-91(158)53-127-113(178)93(59(6)7)147-110(175)81(50-92(159)160)141-108(173)78(46-65-25-18-15-19-26-65)142-112(177)84-28-22-42-148(84)116(181)63(12)130-105(170)80(49-89(123)156)137-98(163)69(118)45-64-23-16-14-17-24-64)115(180)134-70(27-20-21-41-117)101(166)138-76(44-58(4)5)106(171)143-82(54-149)99(164)126-52-90(157)145-94(60(8)9)114(179)135-74(36-40-88(122)155)104(169)139-77(47-66-29-31-68(151)32-30-66)107(172)132-72(34-38-86(120)153)102(167)131-73(35-39-87(121)154)103(168)140-79(48-67-51-125-56-128-67)109(174)144-83(55-150)111(176)133-71(33-37-85(119)152)100(165)129-62(11)97(162)136-75(96(124)161)43-57(2)3;3-2(4,5)1(6)7/h14-19,23-26,29-32,51,56-63,69-84,93-95,149-151H,13,20-22,27-28,33-50,52-55,117-118H2,1-12H3,(H2,119,152)(H2,120,153)(H2,121,154)(H2,122,155)(H2,123,156)(H2,124,161)(H,125,128)(H,126,164)(H,127,178)(H,129,165)(H,130,170)(H,131,167)(H,132,172)(H,133,176)(H,134,180)(H,135,179)(H,136,162)(H,137,163)(H,138,166)(H,139,169)(H,140,168)(H,141,173)(H,142,177)(H,143,171)(H,144,174)(H,145,157)(H,146,158)(H,147,175)(H,159,160);(H,6,7)/t61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,93-,94-,95-;/m0./s1
InChi Key
IVMGPXQXCVBUAP-JGSNPRKVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1 It binds to the orphan receptor GPR39 (Kd = 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin (Item Nos. 15072 | 24458). In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manner and reduces body weight gain and gastric emptying in mice. Obestatin (0.22 g per animal) also reduces food intake and glucose response without affecting plasma insulin responses in fasted high-fat diet fed mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, J.V., Ren, P.C., Avsian-Kretchmer, O., et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science 310(5750), 996-999 (2005).

    2. Subasinghage, A.P., Green, B.D., Flatt, P.R., et al. Metabolic and structural properties of human obestatin {1-23} and two fragment peptides. Peptides 31(9), 1697-1705 (2010).