A peptide hormone
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Obestatin (rat) (trifluoroacetate salt)

Item No. 24553

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-phenylalanyl-L-asparaginyl-L-alanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-L-valylglycyl-L-isoleucyl-L-lysyl-L-leucyl-L-serylglycyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-glutaminyl-L-glutaminyl-L-histidylglycyl-L-arginyl-L-alanyl-L-leucinamide, trifluoroacetate salt
Molecular Formula
C114H174N34O31 • XCF3COOH
Formula Weight
2516.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC(CNC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@H](CC(N)=O)NC([C@@H](N[H])CC2=CC=CC=C2)=O)=O)C)=O)=O)CC3=CC=CC=C3)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)C)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C114H174N34O31.C2HF3O2/c1-12-60(8)93(146-90(157)54-128-111(177)92(59(6)7)147-109(175)81(50-91(158)159)143-108(174)78(46-65-25-17-14-18-26-65)144-110(176)83-29-22-42-148(83)113(179)63(11)132-105(171)80(49-87(120)154)139-97(163)69(116)45-64-23-15-13-16-24-64)112(178)137-71(27-19-20-40-115)101(167)140-76(44-58(4)5)106(172)145-82(55-149)99(165)127-52-88(155)130-61(9)95(161)134-72(34-37-84(117)151)103(169)141-77(47-66-30-32-68(150)33-31-66)107(173)136-73(35-38-85(118)152)102(168)135-74(36-39-86(119)153)104(170)142-79(48-67-51-124-56-129-67)98(164)126-53-89(156)133-70(28-21-41-125-114(122)123)100(166)131-62(10)96(162)138-75(94(121)160)43-57(2)3;3-2(4,5)1(6)7/h13-18,23-26,30-33,51,56-63,69-83,92-93,149-150H,12,19-22,27-29,34-50,52-55,115-116H2,1-11H3,(H2,117,151)(H2,118,152)(H2,119,153)(H2,120,154)(H2,121,160)(H,124,129)(H,126,164)(H,127,165)(H,128,177)(H,130,155)(H,131,166)(H,132,171)(H,133,156)(H,134,161)(H,135,168)(H,136,173)(H,137,178)(H,138,162)(H,139,163)(H,140,167)(H,141,169)(H,142,170)(H,143,174)(H,144,176)(H,145,172)(H,146,157)(H,147,175)(H,158,159)(H4,122,123,125);(H,6,7)/t60-,61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,92-,93-;/m0./s1
InChi Key
IQHGCIXYMXRPAT-JRKJFFPISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.1 It is secreted by rat stomach, brain, perinatal pancreas, myenteric plexus, Leydig cells, and gastrointestinal mucosa and levels are decreased in rat plasma in response to fasting. Total obestatin levels are also reduced in rat fundus and intestine following treadmill exercise training.2 Obestatin inhibits release of insulin, somatostatin, and pancreatic polypeptide and stimulates glucagon release from mouse and rat pancreatic islets in vitro in a concentration-dependent manner.3 In vivo, obestatin (320 μg/kg) reduces food intake without affecting growth hormone or corticosterone release in mice.4 It also inhibits water intake and dehydration-induced vasopressin secretion in response to a hypovolemic challenge in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mészárosová, M., Sirotkin, A.V., Grossmann, R., et al. The effect of obestatin on porcine ovarian granulosa cells. Anim. Reprod. Sci. 108(1-2), 196-207 (2008).

    2. Ghanbari-Niaki, A., Jafari, A., Abednazari, H., et al. Treadmill exercise reduces obestatin concentrations in rat fundus and small intestine. Biochem. Biophys. Res. Commun. 372(4), 741-745 (2008).

    3. Qader, S.S., Håkanson, R., Rehfeld, J.F., et al. Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas. Regul. Pept. 146(1-3), 230-237 (2008).

    4. Bresciani, E., Rapetti, D., Donà, F., et al. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J. Endocrinol. Invest. 29(8), RC16-RC18 (2006).

    5. Samson, W.K., Yosten, G.L., Chang, J.K., et al. Obestatin inhibits vasopressin secretion: Evidence for a physiological action in the control of fluid homeostasis. J. Endocrinol. 196(3), 559-564 (2008).