A TASK-1 potassium channel blocker
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ML-365

Item No. 24666

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-benzamide
CAS Number
947914-18-3
Molecular Formula
C22H20N2O3
Formula Weight
360.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 50 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.1 mg/mlEthanol: 1 mg/ml
λmax
206, 268 nm
SMILES
CC1=CC=CC(C(NC2=CC=CC(NC(C3=C(OC)C=CC=C3)=O)=C2)=O)=C1
InChi Code
InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
InChi Key
UTAJHKSGYJSZBR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $215

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    25 mg

    $487

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    Product Description

    ML-365 is a bis-amide TASK-1 potassium channel blocker (IC50 = 16 nM).1 It is selective for TASK-1 over TASK-3 channels in a QPatch assay (IC50 = 990 nM). It also acts as an antagonist of the metabotropic glutamate receptor mGluR5 (IC50 = 1.35 μM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Flaherty, D.P., Simpson, D.S., Miller, M., et al. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg. Med. Chem. Lett. 24(16), 3968-3973 (2014).

    2. Zhou, Y., Rodriguez, A.L., Williams, R., et al. Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg. Med. Chem. Lett. 19(23), 6502-6506 (2009).