An inducer of cardiomyocyte differentiation
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TA-01

Item No. 24667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-pyridine
CAS Number
1784751-18-3
Molecular Formula
C20H12F3N3
Formula Weight
351.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:6): 0.14 mg/mlDMSO: 3 mg/ml
λmax
289 nm
SMILES
FC1=CC=CC(F)=C1C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2
InChi Code
InChI=1S/C20H12F3N3/c21-14-6-4-12(5-7-14)18-19(13-8-10-24-11-9-13)26-20(25-18)17-15(22)2-1-3-16(17)23/h1-11H,(H,25,26)
InChi Key
TWPJJJZCYVFUOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation.1 It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laco, F., Low, J.-L., Seow, J., et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J. Mol. Cell. Cardiol. 80, 56-70 (2015).