A small molecule agonist of GHS-R1a
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Anamorelin

Item No. 24676

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-1,2,2-trimethylhydrazide, 3-piperidinecarboxylic acid
CAS Number
249921-19-5
Synonyms
  • RC-1291
Molecular Formula
C31H42N6O3
Formula Weight
546.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
219 nm
SMILES
O=C(N(C)N(C)C)[C@]1(CC2=CC=CC=C2)CN(C([C@H](NC(C(C)(N)C)=O)CC3=CNC4=C3C=CC=C4)=O)CCC1
InChi Code
InChI=1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1
InChi Key
VQPFSIRUEPQQPP-MXBOTTGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $128

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    25 mg

    $295

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    50 mg

    $553

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Anamorelin is a small molecule agonist of the growth hormone (GH) secretagogue receptor 1a (GHS-R1a) and a mimetic of ghrelin (Item Nos. 15072 | 24458; Ki = 0.7 nM).1,2 It induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM). In vivo, anamorelin stimulates GH release in sham and vagotomized rats in a dose-dependent manner.1 Anamorelin (3-30 mg/kg) also increases food intake in rats.2 Formulations containing anamorelin have been used to treat cancer anorexia and cachexia in patients with non-small cell lung cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morozumi, N., Hanada, T., Habara, H., et al. The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in rats. Peptides 32(5), 1001-1007 (2011).

    2. Zhang, H., and Garcia, J.M. Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC. Expert Opin. Pharmacother. 16(8), 1245-1253 (2015).