A small molecule agonist of GHS-R1a
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Anamorelin

Item No. 24676

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-1,2,2-trimethylhydrazide, 3-piperidinecarboxylic acid
CAS Number
249921-19-5
Synonyms
  • RC-1291
Molecular Formula
C31H42N6O3
Formula Weight
546.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
219 nm
SMILES
O=C(N(C)N(C)C)[C@]1(CC2=CC=CC=C2)CN(C([C@H](NC(C(C)(N)C)=O)CC3=CNC4=C3C=CC=C4)=O)CCC1
InChi Code
InChI=1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1
InChi Key
VQPFSIRUEPQQPP-MXBOTTGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $75

    Add

    10 mg

    $128

    Add

    25 mg

    $295

    Add

    50 mg

    $553

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Anamorelin is a small molecule agonist of the growth hormone (GH) secretagogue receptor 1a (GHS-R1a) and a mimetic of ghrelin (Item Nos. 15072 | 24458; Ki = 0.7 nM).1,2 It induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM). In vivo, anamorelin stimulates GH release in sham and vagotomized rats in a dose-dependent manner.1 Anamorelin (3-30 mg/kg) also increases food intake in rats.2 Formulations containing anamorelin have been used to treat cancer anorexia and cachexia in patients with non-small cell lung cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morozumi, N., Hanada, T., Habara, H., et al. The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in rats. Peptides 32(5), 1001-1007 (2011).

    2. Zhang, H., and Garcia, J.M. Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC. Expert Opin. Pharmacother. 16(8), 1245-1253 (2015).