A Plk4 inhibitor
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Centrinone

Item No. 24684

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine
CAS Number
1798871-30-3
Synonyms
  • LCR-263
Molecular Formula
C26H25F2N7O6S2
Formula Weight
633.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
234, 298 nm
SMILES
FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCOCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O
InChi Code
InChI=1S/C26H25F2N7O6S2/c1-15-12-21(33-32-15)29-24-23(40-2)25(34-8-10-41-11-9-34)31-26(30-24)42-20-7-6-17(13-18(20)27)43(38,39)14-16-4-3-5-19(22(16)28)35(36)37/h3-7,12-13H,8-11,14H2,1-2H3,(H2,29,30,31,32,33)
InChi Key
HHJSKDRCUMVWKF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $163

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    10 mg

    $289

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    25 mg

    $538

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    Product Description

    Centrinone is an inhibitor of polo-like kinase 4 (Plk4; Ki = 0.16 nM).1 It is greater than 1,100- and 2,800-fold selective for Plk4 over Aurora A and Aurora B kinases, respectively, and a panel of 442 kinases at 100 nM. Centrinone (125 nM) depletes centrosomes and induces apoptosis in HeLa cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, Y.L., Anzola, J.V., Davis, R.L., et al. Reversible centriole depletion with an inhibitor of polo-like kinase 4. Science 348(6239), 1155-1160 (2015).