A neuropeptide
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Neurotensin (8-13) (trifluoroacetate salt)

Item No. 24718

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine, trifluoroacetate salt
Molecular Formula
C38H64N12O8 • XCF3COOH
Formula Weight
817.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C38H64N12O8.C2HF3O2/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41;3-2(4,5)1(6)7/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45);(H,6,7)/t22-,25-,26-,27-,28-,29-,30-;/m0./s1
InChi Key
HOEZVADMUNOUHK-IUBGQBINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $117

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    Product Description

    Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin (Item No. 24717) that binds to rat synaptic membranes with a Ki value of 13 nM.1 It induces contraction of guinea pig ileum (EC50 = 25 nM) and induces contraction of rat fundus equipotently to full length neurotensin (EC50s = 1.29 and 1.58 nM, respectively).1,2 In vivo, neurotensin (8-13) has antinociceptive effects in a mouse tail pressure test (ED50 = 50 nmol per animal).3 It induces extracellular dopamine release in the prefrontal cortex in rats.4 Neurotensin (8-13) also decreases diastolic blood pressure in a dose-dependent manner in normotensive rats without affecting heart rate.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Granier, C., van Rietschoten, J., Kitabgi, P., et al. Synthesis and characterization of neurotensin analogues for structure/activity relationship studies. Acetyl-neurotensin-(8--13) is the shortest analogue with full binding and pharmacological activities. Eur. J. Biochem. 124(1), 117-124 (1982).

    2. Huidobro-Toro, J.P., and Kullak, A. Excitatory neurotensin receptors on the smooth muscle of the rat fundus: Possible implications in gastric motility. Br. J. Pharmacol. 84(4), 897-910 (1985).

    3. Furuta, S., Kisara, K., Sakurada, S., et al. Structure-antinociceptive activity studies with neurotensin. Br. J. Pharmacol. 83(1), 43-48 (1984).

    4. Sotty, F., Brun, P., Leonetti, M., et al. Comparative effects of neurotensin, neurotensin(8-13) and [D-Tyr11]neurotensin applied into the ventral tegmental area on extracellular dopamine in the rat prefrontal cortex and nucleus accumbens. Neuroscience 98(3), 485-492 (2000).

    5. Di Paola, E.D., and Richelson, E. Cardiovascular effects of neurotensin and some analogues on rats. Eur. J. Pharmacol. 175(3), 279-283 (1990).