An endogenous angiotensin II fragment
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Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)

Item No. 24739

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine, 2,2,2-trifluoroacetate
Synonyms
  • Angiotensin (5-8)
Molecular Formula
C26H36N6O5 • XCF3COOH
Formula Weight
512.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
C[C@@H](CC)[C@]([H])(N)C(N[C@@H](CC1=CNC=N1)C(N2[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CCC2)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C26H36N6O5.C2HF3O2/c1-3-16(2)22(27)24(34)30-19(13-18-14-28-15-29-18)25(35)32-11-7-10-21(32)23(33)31-20(26(36)37)12-17-8-5-4-6-9-17;3-2(4,5)1(6)7/h4-6,8-9,14-16,19-22H,3,7,10-13,27H2,1-2H3,(H,28,29)(H,30,34)(H,31,33)(H,36,37);(H,6,7)/t16-,19-,20-,21-,22-;/m0./s1
InChi Key
MMKHYJAANIHLKG-LORYADHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $117

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    Product Description

    Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II (Item No. 17150).1 It inhibits renin (Item No. 10006217) release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre-contracted with phenylephrine (Item Nos. 17205 | 18619; EC50 = 0.28 μM).2,1 In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II.1 It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guethe, L.M., Pelegrini-da-Silva, A., Borelli, K.G., et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience 231, 315-327 (2013).

    2. Naftilan, A.J., and Oparil, S. Inhibition of renin release from rat kidney slices by the angiotensins. Am. J. Physiol. 235(1), F62-F68 (1978).

    3. Genaro, K., Juilano, M.A., Prado, W.A., et al. Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in rats. Behav. Brain Res. 256, 537-544 (2013).