A peptide vasoconstrictor
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Urotensin II (goby) (trifluoroacetate salt)

Item No. 24753

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanylglycyl-L-threonyl-L-alanyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (6→11)-disulfide, trifluoroacetate salt
Synonyms
  • U-II
  • Urotensin II (G. mirabilis)
Molecular Formula
C62H84N14O17S2 • XCF3COOH
Formula Weight
1361.5
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C1=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CC5=CC=CC=C5)=O)CSSC[C@H](N1)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)C.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C62H84N14O17S2.C2HF3O2/c1-31(2)50(62(92)93)76-60(90)47-30-95-94-29-46(73-58(88)45(26-49(80)81)69-53(83)33(4)67-61(91)51(34(5)77)75-48(79)28-66-52(82)32(3)64)59(89)71-42(23-35-13-7-6-8-14-35)55(85)72-44(25-37-27-65-40-16-10-9-15-39(37)40)57(87)68-41(17-11-12-22-63)54(84)70-43(56(86)74-47)24-36-18-20-38(78)21-19-36;3-2(4,5)1(6)7/h6-10,13-16,18-21,27,31-34,41-47,50-51,65,77-78H,11-12,17,22-26,28-30,63-64H2,1-5H3,(H,66,82)(H,67,91)(H,68,87)(H,69,83)(H,70,84)(H,71,89)(H,72,85)(H,73,88)(H,74,86)(H,75,79)(H,76,90)(H,80,81)(H,92,93);(H,6,7)/t32-,33-,34+,41-,42-,43-,44-,45-,46-,47-,50-,51-;/m0./s1
InChi Key
JPLUDFUGUYKDAT-OKRJWCIQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki = 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1 It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2 Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across isolated goby posterior intestine in 5% seawater-adapted solution.3 In vivo, urotensin II (1.5-150 nmol/kg) decreases diastolic blood pressure and increases heart rate in anesthetized rats.4 It also reduces the pressor responses to sympathetic nerve stimulation, norepinephrine (Item No. 16673), and vasopressin in pithed rats when administered at a dose of 150 nmol/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ames, R.S., Sarau, H.M., Chambers, J.K., et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401(6750), 282-286 (1999).

    2. Loretz, C.A., and Assad, J.A. Urotensin II lowers cytoplasmic free calcium concentration in goby enterocytes: Measurements using quin2. Gen. Comp. Endocrinol. 64(3), 355-361 (1986).

    3. Loretz, C.A., Freel, R.W., and Bern, H.A. Specificity of response of intestinal ion transport systems to a pair of natural peptide hormone analogs: Somatostatin and urotensin II. Gen. Comp. Endocrinol. 52(2), 198-206 (1983).

    4. Gibson, A., Wallace, P., and Bern, H.A. Cardiovascular effects of urotensin II in anesthetized and pithed rats. Gen. Comp. Endocrinol. 64(3), 435-439 (1986).