A peptide UTR agonist
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[Orn8]-Urotensin II (human) (trifluoroacetate salt)

Item No. 24754

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5→10)-disulfide, trifluoroacetate salt
Molecular Formula
C63H83N13O18S2 • XCF3COOH
Formula Weight
1374.5
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@]([H])(C(N1CCC[C@H]1C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H](C(O)=O)C(C)C)=O)N2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@H](C(N[C@@H](CC6=CC=C(C=C6)O)C2=O)=O)CCCN)=O)=O)=O)=O)=O)=O)[C@H](O)C)=O)CCC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C63H83N13O18S2.C2HF3O2/c1-32(2)51(63(93)94)74-60(90)47-31-96-95-30-46(72-58(88)45(28-50(81)82)71-61(91)48-16-10-24-76(48)62(92)52(33(3)77)75-53(83)39(65)21-22-49(79)80)59(89)69-42(25-34-11-5-4-6-12-34)55(85)70-44(27-36-29-66-40-14-8-7-13-38(36)40)57(87)67-41(15-9-23-64)54(84)68-43(56(86)73-47)26-35-17-19-37(78)20-18-35;3-2(4,5)1(6)7/h4-8,11-14,17-20,29,32-33,39,41-48,51-52,66,77-78H,9-10,15-16,21-28,30-31,64-65H2,1-3H3,(H,67,87)(H,68,84)(H,69,89)(H,70,85)(H,71,91)(H,72,88)(H,73,86)(H,74,90)(H,75,83)(H,79,80)(H,81,82)(H,93,94);(H,6,7)/t33-,39+,41+,42+,43+,44+,45+,46+,47+,48+,51+,52+;/m1./s1
InChi Key
QCZOSSJKRNMGHK-SCWKBSBTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $214

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    Product Description

    [Orn8]-Urotensin II is a peptide analog of urotensin II (Item No. 24711) and agonist of the urotensin II receptor (UTR; EC50s = 11.74 and 8.7 nM in HEK293 cells expressing the human and rat receptor, respectively).1 It reduces urotensin II-induced contraction of isolated rat aorta (pA2 = 6.56) but has no effect on aortic contraction when used alone at concentrations up to 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Camarda, V., Guerrini, R., Kostenis, E., et al. A new ligand for the urotensin II receptor. Br. J. Pharmacol. 137(3), 311-314 (2002).