A gut peptide hormone agonist of GLP-2R
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GLP-2 (rat) (trifluoroacetate salt)

Item No. 24757

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-L-alanyl-L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-threonyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid, trifluoroacetate salt
Synonyms
  • Glucagon-like Peptide 2
Molecular Formula
C166H256N44O56S • XCF3COOH
Formula Weight
3796.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
OC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC(CNC([C@@H](NC([C@@H](NC([C@@H](N[H])CC1=CN=CN1)=O)C)=O)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)CC(O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)C)=O)=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C166H256N44O56S.C2HF3O2/c1-22-77(11)126(157(257)187-96(45-47-115(169)217)142(242)208-131(84(18)214)162(262)185-94(43-34-35-50-167)141(241)203-129(80(14)25-4)160(260)210-132(85(19)215)163(263)201-112(165(265)266)67-125(232)233)204-152(252)101(55-76(9)10)190-146(246)104(58-89-68-177-93-42-33-32-41-91(89)93)193-148(248)106(61-117(171)219)200-158(258)127(78(12)23-2)205-153(253)103(57-88-39-30-27-31-40-88)191-150(250)110(65-123(228)229)196-138(238)95(44-36-51-176-166(173)174)186-161(261)130(83(17)213)207-135(235)82(16)181-143(243)99(53-74(5)6)189-147(247)105(60-116(170)218)195-151(251)111(66-124(230)231)197-144(244)100(54-75(7)8)199-159(259)128(79(13)24-3)206-164(264)133(86(20)216)209-154(254)107(62-118(172)220)194-140(240)98(49-52-267-21)184-139(239)97(46-48-120(222)223)183-149(249)109(64-122(226)227)198-156(256)114(72-212)202-145(245)102(56-87-37-28-26-29-38-87)192-155(255)113(71-211)182-119(221)70-178-137(237)108(63-121(224)225)188-134(234)81(15)180-136(236)92(168)59-90-69-175-73-179-90;3-2(4,5)1(6)7/h26-33,37-42,68-69,73-86,92,94-114,126-133,177,211-216H,22-25,34-36,43-67,70-72,167-168H2,1-21H3,(H2,169,217)(H2,170,218)(H2,171,219)(H2,172,220)(H,175,179)(H,178,237)(H,180,236)(H,181,243)(H,182,221)(H,183,249)(H,184,239)(H,185,262)(H,186,261)(H,187,257)(H,188,234)(H,189,247)(H,190,246)(H,191,250)(H,192,255)(H,193,248)(H,194,240)(H,195,251)(H,196,238)(H,197,244)(H,198,256)(H,199,259)(H,200,258)(H,201,263)(H,202,245)(H,203,241)(H,204,252)(H,205,253)(H,206,264)(H,207,235)(H,208,242)(H,209,254)(H,210,260)(H,222,223)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,232,233)(H,265,266)(H4,173,174,176);(H,6,7)/t77-,78-,79-,80-,81-,82-,83+,84+,85+,86+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,126-,127-,128-,129-,130-,131-,132-,133-;/m0./s1
InChi Key
WUMKGBDFIGGKQZ-VRJUPRFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Product Description

    Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone agonist of the GLP-2 receptor (GLP-2R).1 It increases cAMP levels in COS cells expressing GLP-2R with an EC50 value of 0.58 nM. GLP-2 is primarily produced by enteroendocrine L cells of the small and large intestine but can also be found in the hypothalamus.1,2 In vivo, GLP-2 (43.75 μg twice per day for 10 days) increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine in mice.3 GLP-2 (10 μg per animal) reduces two-hour food intake in rats by 37% with no reduction in water intake.2 Secretion of GLP-2 in rats is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Munroe, D.G., Gupta, A.K., Kooshesh, F., et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc. Natl. Acad. Sci. USA 96(4), 1569-1573 (1999).

    2. Tang-Christensen, M., Larsen, P.J., Thulesen, J., et al. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat. Med. 6(7), 802-807 (2000).

    3. Drucker, D.J., Erlich, P., Asa, S.L., et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. USA 93(15), 7911-7916 (1996).

    4. Sato, S., Hokari, R., Kurihara, C., et al. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion. Am. J. Physiol Gastrointest. Liver Physiol. 304(8), 304-308 (2013).