An endogenous peptide
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Biochemicals
Peptides

Research Area

Cancer

PACAP-related Peptide (human) (trifluoroacetate salt)

Item No. 24772

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-valyl-L-alanyl-L-histidylglycyl-L-isoleucyl-L-leucyl-L-asparaginyl-L-α-glutamyl-L-alanyl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-α-aspartyl-L-glutaminyl-L-leucyl-L-seryl-L-alanylglycyl-L-lysyl-L-histidyl-L-leucyl-L-glutaminyl-L-seryl-L-leucyl-L-valyl-L-alanine, trifluoroacetate salt
Synonyms
  • Pituitary Adenylate Cyclase-activating Peptide-related Peptide (human)
  • PRP (human)
Molecular Formula
C139H229N41O42 • XCF3COOH
Formula Weight
3146.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(NCC(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O)C)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)C)=O)=O)CC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C139H229N41O42.C2HF3O2/c1-23-72(18)111(177-104(188)59-152-116(199)94(51-78-56-148-62-153-78)166-114(197)75(21)157-134(217)108(69(12)13)178-115(198)81(142)53-106(191)192)137(220)174-91(48-67(8)9)124(207)171-96(54-102(145)186)129(212)164-87(38-41-105(189)190)117(200)156-74(20)113(196)165-93(50-77-32-34-80(183)35-33-77)127(210)161-84(31-28-44-150-139(146)147)119(202)160-83(30-25-27-43-141)122(205)179-110(71(16)17)136(219)173-90(47-66(6)7)125(208)172-97(55-107(193)194)130(213)163-85(36-39-100(143)184)120(203)167-89(46-65(4)5)126(209)176-98(60-181)132(215)155-73(19)112(195)151-58-103(187)159-82(29-24-26-42-140)118(201)170-95(52-79-57-149-63-154-79)128(211)168-88(45-64(2)3)123(206)162-86(37-40-101(144)185)121(204)175-99(61-182)133(216)169-92(49-68(10)11)131(214)180-109(70(14)15)135(218)158-76(22)138(221)222;3-2(4,5)1(6)7/h32-35,56-57,62-76,81-99,108-111,181-183H,23-31,36-55,58-61,140-142H2,1-22H3,(H2,143,184)(H2,144,185)(H2,145,186)(H,148,153)(H,149,154)(H,151,195)(H,152,199)(H,155,215)(H,156,200)(H,157,217)(H,158,218)(H,159,187)(H,160,202)(H,161,210)(H,162,206)(H,163,213)(H,164,212)(H,165,196)(H,166,197)(H,167,203)(H,168,211)(H,169,216)(H,170,201)(H,171,207)(H,172,208)(H,173,219)(H,174,220)(H,175,204)(H,176,209)(H,177,188)(H,178,198)(H,179,205)(H,180,214)(H,189,190)(H,191,192)(H,193,194)(H,221,222)(H4,146,147,150);(H,6,7)/t72-,73-,74-,75-,76-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-;/m0./s1
InChi Key
NSOUCWVGKFZOGP-ORBXSARKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $401

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    Product Description

    PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin (Item No. 24561), glucagon (Item No. 24204), glucagon-like peptide-1 (GLP-1; Item No. 24460), GLP-2 (Item No. 24414), and pituitary adenylate cyclase-activating polypeptide (PACAP; Item Nos. 24769 | 24770).1,2 It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP).3 PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vaudry, D., Falluel-Morel, A., Bourgault, S., et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol. Rev. 61(3), 283-357 (2009).

    2. Tam, J.K., Lee, L.T., and Chow, B.K. PACAP-related peptide (PRP)--molecular evolution and potential functions. Peptides 28(9), 1920-1929 (2007).

    3. Fahrenkrug, J., Buhl, T., and Hannibal, J. PreproPACAP-derived peptides occur in VIP-producing tumours and co-exist with VIP. Regul. Pept. 58(3), 89-98 (1995).

    4. Okazaki, K., Kimura, C., Kosaka, T., et al. Expression of human pituitary adenylate cyclase activating polypeptide (PACAP) cDNA in CHO cells and characterization of the products. FEBS Lett. 298(1), 49-56 (1992).