A peptide agonist for Y₁, Y₂, Y₅, and Y₆ receptors

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Product Type

Small Molecule Modulators

Receptor Pharmacology

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Endocrinology & Metabolism

Behavioral Neuroscience

Food Intake

Neuroendocrinology

Peptide YY (human) (trifluoroacetate salt)

Name: Peptide YY (human) (trifluoroacetate salt)
Brand: -

Item No. 24776

Peptide YY (human) (trifluoroacetate salt) (Peptide Tyrosine Tyrosine, PYY)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

L-tyrosyl-L-prolyl-L-isoleucyl-L-lysyl-L-prolyl-L-α-glutamyl-L-alanyl-L-prolylglycyl-L-α-glutamyl-L-α-aspartyl-L-alanyl-L-seryl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-asparaginyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-alanyl-L-seryl-L-leucyl-L-arginyl-L-histidyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-leucyl-L-valyl-L-threonyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide, trifluoroacetate salt

Synonyms

Peptide Tyrosine Tyrosine
PYY

Molecular Formula

C₁₉₄H₂₉₅N₅₅O₅₇ • XCF₃COOH

Formula Weight

4309.8

Purity

≥95%

Formulation (Request formulation change)

A lyophilized powder

Solubility(Learn about Variance in Solubility)

Water: 1 mg/ml

SMILES

NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(CNC([C@@H]2CCCN2C([C@@H](NC([C@H](CCC(O)=O)NC([C@@H]3CCCN3C([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])NC([C@@H]4CCCN4C([C@@H](N[H])CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)CC7=CC=C(O)C=C7)=O)C)=O)=O)=O)=O)CC8=CN=CN8)=O)CC9=CC=C(O)C=C9)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC%10=CC=C(O)C=C%10)=O.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C194H295N55O57.C2HF3O2/c1-17-99(12)154(244-183(299)143-36-25-73-247(143)188(304)115(196)80-104-37-47-110(253)48-38-104)185(301)228-125(28-18-19-67-195)189(305)248-74-26-34-141(248)181(297)225-122(59-64-149(264)265)159(275)218-102(15)187(303)246-72-24-33-140(246)180(296)214-90-147(261)219-120(58-63-148(262)263)164(280)240-137(88-152(270)271)169(285)217-101(14)158(274)242-139(92-251)190(306)249-75-27-35-142(249)182(298)226-124(61-66-151(268)269)166(282)224-123(60-65-150(266)267)167(283)230-128(77-95(4)5)171(287)238-135(86-145(198)259)176(292)222-117(30-21-69-211-192(203)204)162(278)234-132(83-107-43-53-113(256)54-44-107)174(290)235-131(82-106-41-51-112(255)52-42-106)168(284)216-100(13)157(273)241-138(91-250)179(295)233-127(76-94(2)3)170(286)221-118(31-22-70-212-193(205)206)163(279)237-134(85-109-89-209-93-215-109)175(291)236-133(84-108-45-55-114(257)56-46-108)173(289)231-129(78-96(6)7)172(288)239-136(87-146(199)260)177(293)232-130(79-97(8)9)178(294)243-153(98(10)11)184(300)245-155(103(16)252)186(302)227-119(32-23-71-213-194(207)208)160(276)223-121(57-62-144(197)258)165(281)220-116(29-20-68-210-191(201)202)161(277)229-126(156(200)272)81-105-39-49-111(254)50-40-105;3-2(4,5)1(6)7/h37-56,89,93-103,115-143,153-155,250-257H,17-36,57-88,90-92,195-196H2,1-16H3,(H2,197,258)(H2,198,259)(H2,199,260)(H2,200,272)(H,209,215)(H,214,296)(H,216,284)(H,217,285)(H,218,275)(H,219,261)(H,220,281)(H,221,286)(H,222,292)(H,223,276)(H,224,282)(H,225,297)(H,226,298)(H,227,302)(H,228,301)(H,229,277)(H,230,283)(H,231,289)(H,232,293)(H,233,295)(H,234,278)(H,235,290)(H,236,291)(H,237,279)(H,238,287)(H,239,288)(H,240,280)(H,241,273)(H,242,274)(H,243,294)(H,244,299)(H,245,300)(H,262,263)(H,264,265)(H,266,267)(H,268,269)(H,270,271)(H4,201,202,210)(H4,203,204,211)(H4,205,206,212)(H4,207,208,213);(H,6,7)/t99-,100-,101-,102-,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,153-,154-,155-;/m0./s1

InChi Key

GRVCUYCCTMXBGK-CPOVZGDBSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

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500 µg

$202

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1 mg

$361

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OBESITY RESEARCH SOLUTIONS

Product Description

Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y₁, Y₂, Y₅, and Y₆ with EC₅₀ values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-induced cAMP accumulation.^1,2 PYY is cleaved in vivo to PYY (3-36) (Item No. 16502). Release of PYY occurs postprandially in proportion to calorie intake from intestinal enteroendocrine L cells, indicating it may be a satiety signal.³ In humans, PYY inhibits food intake and gastrointestinal transit in both lean and obese subjects.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Gerald, C., Walker, M.W., Criscione, L., et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382(6587), 168-171 (1996).

2. Mullins, D.E., Guzzi, M., Xia, L., et al. Pharmacological characterization of the cloned neuropeptide Y y6 receptor. Eur. J. Pharmacol. 395(2), 87-93 (2000).

3. Holzer, P., Reichmann, F., and Farzi, A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 46(6), 261-274 (2012).

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