A truncated form of adrenomedullin
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Adrenomedullin (13-52) (human) (trifluoroacetate salt)

Item No. 24891

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threonyl-L-cysteinyl-L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleucyl-L-tyrosyl-L-glutaminyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-aspartyl-L-asparaginyl-L-valyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-lysyl-L-isoleucyl-L-seryl-L-prolyl-L-glutaminylglycyl-L-tyrosinamide, cyclic (4→9)-disulfide, trifluoroacetate salt
Synonyms
  • ADM
  • AM
Molecular Formula
C200H308N58O59S2 • XCF3COOH
Formula Weight
4533.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC(CNC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@@H](NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N3)CSSC[C@H](NC(CNC([C@@H](NC([C@H](CO)N[H])=O)CC4=CC=CC=C4)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CC8=CC=CC=C8)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C200H308N58O59S2.C2HF3O2/c1-16-101(9)157(254-176(295)126(64-68-147(209)270)233-179(298)133(83-113-88-216-97-222-113)237-163(282)103(11)223-177(296)128(77-98(3)4)239-168(287)117(45-27-31-69-201)227-173(292)125(63-67-146(208)269)236-191(310)156(100(7)8)252-196(315)161(107(15)264)256-187(306)141-96-319-318-95-140(226-150(273)90-220-166(285)129(238-164(283)116(205)92-259)79-108-39-21-18-22-40-108)186(305)231-121(49-35-73-217-199(212)213)171(290)240-130(80-109-41-23-19-24-42-109)167(286)221-91-151(274)250-159(105(13)262)194(313)249-141)192(311)245-131(82-112-55-59-115(266)60-56-112)178(297)232-124(62-66-145(207)268)174(293)241-132(81-110-43-25-20-26-44-110)183(302)255-160(106(14)263)195(314)246-137(87-154(279)280)181(300)229-119(47-29-33-71-203)169(288)243-135(85-152(275)276)180(299)228-118(46-28-32-70-202)170(289)244-136(86-153(277)278)182(301)242-134(84-148(210)271)184(303)251-155(99(5)6)190(309)224-104(12)197(316)257-75-37-51-142(257)188(307)234-122(50-36-74-218-200(214)215)172(291)247-138(93-260)185(304)230-120(48-30-34-72-204)175(294)253-158(102(10)17-2)193(312)248-139(94-261)198(317)258-76-38-52-143(258)189(308)235-123(61-65-144(206)267)165(284)219-89-149(272)225-127(162(211)281)78-111-53-57-114(265)58-54-111;3-2(4,5)1(6)7/h18-26,39-44,53-60,88,97-107,116-143,155-161,259-266H,16-17,27-38,45-52,61-87,89-96,201-205H2,1-15H3,(H2,206,267)(H2,207,268)(H2,208,269)(H2,209,270)(H2,210,271)(H2,211,281)(H,216,222)(H,219,284)(H,220,285)(H,221,286)(H,223,296)(H,224,309)(H,225,272)(H,226,273)(H,227,292)(H,228,299)(H,229,300)(H,230,304)(H,231,305)(H,232,297)(H,233,298)(H,234,307)(H,235,308)(H,236,310)(H,237,282)(H,238,283)(H,239,287)(H,240,290)(H,241,293)(H,242,301)(H,243,288)(H,244,289)(H,245,311)(H,246,314)(H,247,291)(H,248,312)(H,249,313)(H,250,274)(H,251,303)(H,252,315)(H,253,294)(H,254,295)(H,255,302)(H,256,306)(H,275,276)(H,277,278)(H,279,280)(H4,212,213,217)(H4,214,215,218);(H,6,7)/t101-,102-,103-,104-,105+,106+,107+,116-,117-,118-,119-,120-,121-,122-,123-,124-,1
InChi Key
ZFOARKDSHPKCOT-ZBKJENTOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) (Item No. 24889).1 It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II (Item No. 17150) and endothelin-1 (Item No. 24127) from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 (Item No. 16450) in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure.2 It also potentiates inflammatory edema and neutrophil accumulation in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tian, Q., Zhao, D., Tan, D.Y., et al. Vasodilator effect of human adrenomedullin (13-52) on hypertensive rats. Can. J. Physiol. Pharmacol. 73(7), 1065-1069 (1995).

    2. Lippton, H., Chang, J.K., Hao, Q., et al. Adrenomedullin dilates the pulmonary vascular bed in vivo. J. Appl. Physiol. 76(5), 2154-2156 (1994).

    3. Chu, D.Q., Choi, M.K., Foster, P., et al. A comparative study of the ability of calcitonin gene-related peptide and adrenomedullin13 - 52 to modulate microvascular but not thermal hyperalgesia responses. Br. J. Pharmacol. 130(7), 1589-1596 (2000).