A peptide with diverse biological activities
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Adrenomedullin (1-52) (human) (trifluoroacetate salt)

Item No. 24889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
adrenomedullin (human), trifluoroacetate salt
Synonyms
  • ADM
  • AM
Molecular Formula
C264H406N80O77S3 • XCF3COOH
Formula Weight
6028.7
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC(CNC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@@H](NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N3)CSSC[C@H](NC(CNC([C@@H](NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])CC4=CC=C(O)C=C4)=O)=O)=O)=O)CCSC)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC8=CN=CN8)=O)=O)=O)CC9=CC=C(O)C=C9)=O)=O)CC%10=CC=CC=C%10)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC%11=CC=C(O)C=C%11)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C264H406N80O77S3.C2HF3O2/c1-19-133(11)208(254(415)329-173(109-146-69-75-150(354)76-70-146)236(397)312-162(79-85-192(272)357)228(389)322-174(108-143-53-31-24-32-54-143)243(404)341-211(138(16)350)257(418)330-181(116-205(372)373)241(402)306-154(57-35-39-92-267)222(383)327-179(114-203(368)369)240(401)305-153(56-34-38-91-266)223(384)328-180(115-204(370)371)242(403)326-178(113-198(278)363)244(405)337-206(131(7)8)252(413)299-136(14)259(420)343-98-45-63-188(343)250(411)315-159(62-44-97-292-264(286)287)226(387)331-182(122-345)245(406)308-155(58-36-40-93-268)231(392)339-209(134(12)20-2)255(416)334-185(125-348)260(421)344-99-46-64-189(344)251(412)316-161(78-84-191(271)356)217(378)293-118-199(364)300-167(213(279)374)104-145-67-73-149(353)74-68-145)340-232(393)165(82-88-195(275)360)313-237(398)175(110-147-117-288-128-297-147)318-214(375)135(13)298-233(394)169(102-130(5)6)319-221(382)152(55-33-37-90-265)304-227(388)164(81-87-194(274)359)317-253(414)207(132(9)10)338-258(419)212(139(17)351)342-249(410)187-127-424-423-126-186(248(409)309-157(60-42-95-290-262(282)283)224(385)320-170(105-140-47-25-21-26-48-140)218(379)296-121-202(367)336-210(137(15)349)256(417)335-187)302-201(366)120-295-219(380)171(106-141-49-27-22-28-50-141)321-247(408)184(124-347)332-225(386)158(61-43-96-291-263(284)285)307-234(395)168(101-129(3)4)301-200(365)119-294-216(377)160(77-83-190(270)355)310-235(396)172(107-142-51-29-23-30-52-142)323-238(399)177(112-197(277)362)325-239(400)176(111-196(276)361)324-230(391)166(89-100-422-18)314-246(407)183(123-346)333-229(390)163(80-86-193(273)358)311-220(381)156(59-41-94-289-261(280)281)303-215(376)151(269)103-144-65-71-148(352)72-66-144;3-2(4,5)1(6)7/h21-32,47-54,65-76,117,128-139,151-189,206-212,345-354H,19-20,33-46,55-64,77-116,118-127,265-269H2,1-18H3,(H2,270,355)(H2,271,356)(H2,272,357)(H2,273,358)(H2,274,359)(H2,275,360)(H2,276,361)(H2,277,362)(H2,278,363)(H2,279,374)(H,288,297)(H,293,378)(H,294,377)(H,295,380)(H,296,379)(H,298,394)(H,299,413)(H,300,364)(H,30
InChi Key
YULATDANFPGQAF-XKBWIQTRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $575

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    Product Description

    Adrenomedullin (1-52) is a peptide with diverse biological activities.1,2,3,4 It belongs to the calcitonin family of peptides, which includes amylin (Item Nos. 24274 | 24275), calcitonin gene-related peptide (Item Nos. 24405 | 24725 | 24728), and calcitonin (Item Nos. 24409 | 24410).1 Adrenomedullin (1-52) is expressed in pheochromocytomas, adrenal medulla, heart, lung, and kidney as well as human umbilical vein endothelial cells (HUVECs) and in human glomerular epithelial and hematopoietic cell lines. In vivo, adrenomedullin (1-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 (Item No. 16450) in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure.2 It reduces mechanical ventilation-induced lung injury and sepsis as well as liver and gut injury induced by ventilator-induced lung injury in a mouse model of pneumococcal pneumonia infection.3 Adrenomedullin (1-52) improves survival and inhibits cardiac tissue damage induced by doxorubicin (Item No. 15007) in mice.4 Adrenomedullin (1-52) also reduces hyperoxia-induced right ventricular hypertrophy and artery thickness in a rat model of bronchopulmonary dysplasia.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. García-Ponce, A., Chánez Paredes, S., Castro Ochoa, K.F., et al. Regulation of endothelial and epithelial barrier functions by peptide hormones of the adrenomedullin family. Tissue Barriers 4(4), e1228439 (2016).

    2. Lippton, H., Chang, J.K., Hao, Q., et al. Adrenomedullin dilates the pulmonary vascular bed in vivo. J. Appl. Physiol. 76(5), 2154-2156 (1994).

    3. Müller-Redetzky, H.C., Will, D., Hellwig, K., et al. Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: Protection by adrenomedullin. Crit. Care 18(2), R73 (2014).

    4. Yoshizawa, T., Takizawa, S., Shimada, S., et al. Effects of adrenomedullin on doxorubicin-induced cardiac damage in mice. Biol. Pharm. Bull. 39(5), 737-746 (2016).