A depolarizing neuromuscular blocking agent
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Decamethonium (bromide)

Item No. 24907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N1,N1,N10,N10,N10-hexamethyl-1,10-decanediaminium, dibromide
CAS Number
541-22-0
Molecular Formula
C16H38N2 • 2Br
Formula Weight
418.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 16 mg/mlEthanol: 33 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]
InChi Code
InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
InChi Key
HLXQFVXURMXRPU-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $86

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    10 g

    $153

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    Product Description

    Decamethonium is a depolarizing neuromuscular blocking agent.1 It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs).2 Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 µM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 µM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor).3 It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively.1,4 Formulations containing decamethonium have been used to induce paralysis during anesthesia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Paton, W.D., and Zaimis, E.J. The action of D-tubocurarine and of decamethonium on respiratory and other muscles in the cat. J. Physiol. 112(3-4), 311-331 (1951).

    2. Papke, R.L., Wecker, L., and Stitzel, J.A. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 333(2), 501-518 (2010).

    3. Eaton, J.B., Peng, J.-H., Schroeder, K.M., et al. Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Mol. Pharmacol. 64(6), 1283-1294 (2003).

    4. Robaire, B., and Kato, G. Effects of edrophonium, serine, decamethonium, d-tubocurarine, and gallamine on the kinetics of membrane-bound and solubilized eel acetylcholinesterase. Mol. Pharmacol. 11(6), 722-734 (1974).