A dopamine metabolite
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3,4-Dihydroxyphenylacetic Acid

Item No. 24912

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydroxy-benzeneacetic acid
CAS Number
102-32-9
Synonyms
  • DOPAC
  • NSC 73191
Molecular Formula
C8H8O4
Formula Weight
168.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
280 nm
SMILES
OC1=C(O)C=CC(CC(O)=O)=C1
InChi Code
InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)
InChi Key
CFFZDZCDUFSOFZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine (Item No. 21992) formed through deamination by monoamine oxidase (MAO).1 DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice. DOPAC oxidation is catalyzed by α-synuclein and oxidized DOPAC binds to monomeric α-synuclein preventing fibrillation.2 In vivo, foot shock stress increases DOPAC levels relative to control by approximately 45% in the prefrontal cortex and by 15% in the olfactory tubercles and ventral tegmental area (VTA) in rats.3

    WARNING This product is not for human or veterinary use.