A phenol with diverse biological activities
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Vanillic Acid

Item No. 39643

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-methoxy-benzoic acid
CAS Number
121-34-6
Synonyms
  • NSC 3987
  • NSC 674322
Molecular Formula
C8H8O4
Formula Weight
168.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(C1=CC=C(C(OC)=C1)O)O
InChi Code
InChI=1S/C8H8O4/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,9H,1H3,(H,10,11)
InChi Key
WKOLLVMJNQIZCI-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $44

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    50 g

    $80

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    100 g

    $132

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    250 g

    $307

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Vanillic acid is a phenol that has been found in A. sinensis and has diverse biological activities.1,2,3,4 It inhibits biofilm formation by carbapenem-resistant E. hormaechei (CREH; MIC = 0.8 mg/ml).1 Vanillic acid (12 µg/ml) inhibits cell death induced by the antitumor agent doxorubicin (Item No. 15007) in H9c2 rat cardiomyocytes.2 In vivo, vanillic acid (10, 20, and 40 mg/kg per day) reduces cardiac levels of lactate dehydrogenase, cardiac troponin-1, and malondialdehyde (MDA) in a rat model of doxorubicin-induced cardiotoxicity. It reduces hyperglycemia and renal levels of thiobarbituric acid reactive substances (TBARS), TNF-α, and NF-κB, as well as attenuates impaired renal function in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) and nicotinamide (Item No. 11127).3 Vanillic acid (25 and 50 mg/kg) also reduces bronchoalveolar lavage fluid (BALF) inflammatory cell infiltration and airway inflammation in a rat model of ovalbumin-induced asthma.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qian, W., Yang, M., Wang, T., et al. Antibacterial mechanism of vanillic acid on physiological, morphological, and biofilm properties of carbapenem-resistant Enterobacter hormaechei. J. Food Prot. 83(4), 576-583 (2020).

    2. Yalameha, B., Nejabati, H.R., and Nouri, M. Cardioprotective potential of vanillic acid. Clin. Exp. Pharmacol. Physiol. 50(3), 193-204 (2023).

    3. Singh, B., Kumar, A., Singh, H., et al. Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF-κB, TNF-α and COX-2 proteins in rats. Phytother. Res. 36(3), 1338-1352 (2022).

    4. Bai, F., Fang, L., Hu, H., et al. Vanillic acid mitigates the ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation. Biosci. Biotechnol. Biochem. 83(3), 531-537 (2019).