A coumarin derivative
Related Products
Isomer(s)
30320Pteryxin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Natural Products
Coumarins

Research Area

Immunology & Inflammation

(+)-Praeruptorin A

Item No. 24915

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2Z)-2-methyl-2-butenoic acid, (9S,10S)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester
CAS Number
73069-27-9
Molecular Formula
C21H22O7
Formula Weight
386.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
219, 324 nm
SMILES
O=C1C=CC(C=CC2=C3[C@H](OC(C)=O)[C@H](OC(/C(C)=C\C)=O)C(C)(C)O2)=C3O1
InChi Code
InChI=1S/C21H22O7/c1-6-11(2)20(24)27-19-18(25-12(3)22)16-14(28-21(19,4)5)9-7-13-8-10-15(23)26-17(13)16/h6-10,18-19H,1-5H3/b11-6-/t18-,19-/m0/s1
InChi Key
XGPBRZDOJDLKOT-NXIDYTHLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 mg

    $53

    Add

    50 mg

    $98

    Add

    100 mg

    $174

    Add
    Product Description

    (+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum.1 It prevents LPS-induced increases in IL-1β and TNF-α in a concentration-dependent manner when used at concentrations ranging from 6.25 to 100 µM and IL-6 at concentrations ranging from 25 to 100 µM.2 It inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% when used at concentrations of 4.8 and 30 µM, respectively.3 Topical administration of (+)-praeruptorin A (0.3 µmol/cm2) reduces edema by 22% in a croton oil mouse model of inflammation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zheng-Xiong, G., Huang, B.-S., She, Q.-L., et al. Study on the chemical constituents of the Chinese medicinal plant, Peucedanum praeruptorum Dunn. Structures of four new coumarins. Yaoxue Xuebao 14(8), 486-496 (1979).

    2. Lee, J., Lee, Y.J., Kim, J., et al. Pyranocoumarins from root extracts of Peucedanum praeruptorum Dunn with multidrug resistance reversal and anti-inflammatory activities. Molecules 20(12), 20967-20978 (2015).

    3. Zhao, N.C., Jin, W.B., Zhang, X.H., et al. Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries. Biol. Pharm. Bull. 22(9), 984-987 (1999).

    4. Menghini, L., Epifano, F., Genovese, S., et al. Antiinflammatory activity of coumarins from Ligusticum lucidum Mill. subsp. cuneifolium (Guss.) Tammaro (Apiaceae). Phytother. Res. 24(11), 1697-1699 (2010).