Pteryxin

Pteryxin is a coumarin that has been found in A. furcijuga and has diverse biological activities.^1,2,3,4 It inhibits LPS-induced nitric oxide production in mouse peritoneal macrophages (IC₅₀ = 20 µM).¹ Pteryxin (100 µg/ml) completely inhibits collagen-induced aggregation of isolated rabbit platelets.² It inhibits butyrylcholinesterase (BChE; IC₅₀ = 12.96 µg/ml).³ Pteryxin reduces triacylglycerol levels and expression of the genes encoding sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthase (FASN), and acetyl-coenzyme A carboxylase 1 (ACC1) in 3T3-L1 adipocytes and HepG2 cells.⁴

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1. Matsuda, H., Murakami, T., Kageura, T., et al. Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga. Bioorg. Med. Chem. Lett. 8(16), 2191-2196 (1998).

2. Chen, I.-S., Chang, C.-T., Sheen, W.-S., et al. Coumarins and antiplatelet aggregation constituents from formosan Peucedanum japonicum. Phytochemistry 41(2), 525-530 (1996).

3. Orhan, I.E., Senol, F.S., Shekfeh, S., et al. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food Chem. Toxicol. 109(Pt 2), 970-974 (2017).

4. Nugara, R.N., Inafuku, M., Takara, K., et al. Pteryxin: A coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network. Nutrition 30(10), 1177-1184 (2014).