Scutellarein

Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities.^1,2,3,4,5,6 It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml.² Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC₅₀s = 12 and 0.86 μM, respectively).^3,4 It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.⁵ In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.⁶

WARNING This product is not for human or veterinary use.

1. Hui, K.M., Wang, X.H., and Xue, H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med. 66(1), 91-93 (2000).

2. Siraichi, J.T.G., Felipe, D.F., Brambilla, L.Z.S., et al. Antioxidant capacity of the leaf extract obtained from Arrabidaea chica cultivated in Southern Brazil. PLoS One 8(8), e72733 (2013).

3. Kawabata, J., Mizuhata, K., Sato, E., et al. 6-Hydroxyflavonoids as α-glucosidase inhibitors from marjoram (Origanum majorana) leaves. Biosci. Biotechnol. Biochem. 67(2), 445-447 (2003).

4. Yu, M.-S., Lee, J., Lee, J.M., et al. Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorg. Med. Chem. Lett. 22(12), 4049-4054 (2012).

5. Sung, N.Y., Kim, M.-Y., and Cho, J.Y. Scutellarein reduces inflammatory responses by inhibiting Src kinase activity. Korean J. Physiol. Pharmacol. 19(5), 441-449 (2015).

6. Shi, X., Chen, G., Liu, X., et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. Int. J. Mol. Med. 35(1), 31-38 (2015).