An acetylated form of ghrelin
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Ghrelin (rat) (acetyl) (trifluoroacetate salt)

Item No. 24982

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-seryl-O-acetyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt
Molecular Formula
C141H233N45O42 • XCF3COOH
Formula Weight
3230.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(C)N(C([C@H](CO)NC(CN[H])=O)=O)[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N4CCC[C@H]4C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C141H233N45O42.C2HF3O2/c1-74(2)63-94(125(213)174-92(43-49-109(151)195)135(223)182-59-23-38-103(182)132(220)175-93(139(227)228)35-22-58-158-141(154)155)176-119(207)82(30-12-17-53-143)163-114(202)77(6)161-130(218)101-36-25-61-184(101)138(226)104-39-26-62-185(104)134(222)91(33-15-20-56-146)173-118(206)84(32-14-19-55-145)168-129(217)98(69-187)180-124(212)89(44-50-111(197)198)170-116(204)83(31-13-18-54-144)166-117(205)85(34-21-57-157-140(152)153)167-121(209)87(41-47-107(149)193)169-120(208)86(40-46-106(148)192)164-113(201)76(5)160-115(203)81(29-11-16-52-142)165-122(210)88(42-48-108(150)194)171-128(216)97(66-80-68-156-73-159-80)178-123(211)90(45-51-112(199)200)172-131(219)102-37-24-60-183(102)136(224)99(70-188)181-126(214)95(64-75(3)4)177-127(215)96(65-79-27-9-8-10-28-79)179-133(221)105(72-190)186(78(7)191)137(225)100(71-189)162-110(196)67-147;3-2(4,5)1(6)7/h8-10,27-28,68,73-77,81-105,187-190H,11-26,29-67,69-72,142-147H2,1-7H3,(H2,148,192)(H2,149,193)(H2,150,194)(H2,151,195)(H,156,159)(H,160,203)(H,161,218)(H,162,196)(H,163,202)(H,164,201)(H,165,210)(H,166,205)(H,167,209)(H,168,217)(H,169,208)(H,170,204)(H,171,216)(H,172,219)(H,173,206)(H,174,213)(H,175,220)(H,176,207)(H,177,215)(H,178,211)(H,179,221)(H,180,212)(H,181,214)(H,197,198)(H,199,200)(H,227,228)(H4,152,153,157)(H4,154,155,158);(H,6,7)/t76-,77-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-;/m0./s1
InChi Key
CPWAGHMOIVWYMZ-GLMJMAPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $258

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).1,2 Ghrelin requires an n-octanoyl modification at serine 3 for binding to the GH secretagogue receptor (GHS-R).3 Ghrelin (rat) (acetyl) is form of ghrelin that is acetylated at serine 3. Acetylated ghrelin is 20-fold less potent than n-octanoyl ghrelin in HEK-293 cells transfected with human GHS-R (IC50 = >2,000 nM; EC50 = 2,000 nM in an aequorin bioluminescence assay).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kojima, M., Hosoda, H., Date, Y., et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402(6762), 656-660 (1999).

    2. Dickson, S.L., Egecioglu, E., Landgren, S., et al. The role of the central ghrelin system in reward from food and chemical drugs. Mol. Cell Endocrinol. 340(1), 80-87 (2011).

    3. Resh, M.D. Fatty acylation of proteins: The long and the short of it. Prog. Lipid Res. 63, 120-131 (2016).

    4. Bednarek, M.A., Feighner, S.D., Pong, S.-S., et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J. Med. Chem. 43(23), 4370-4376 (2000).