A neuropeptide involved in regulating food intake
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Prolactin-Releasing Peptide (1-31) (human) (trifluoroacetate salt)

Item No. 24986

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-arginyl-L-threonyl-L-histidyl-L-arginyl-L-histidyl-L-seryl-L-methionyl-L-α-glutamyl-L-isoleucyl-L-arginyl-L-threonyl-L-prolyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-prolyl-L-alanyl-L-tryptophyl-L-tyrosyl-L-alanyl-L-seryl-L-arginylglycyl-L-isoleucyl-L-arginyl-L-prolyl-L-valylglycyl-L-arginyl-L-phenylalaninamide, trifluoroacetate salt
Synonyms
  • Human PrRP-31
  • PrRP (1-31)
Molecular Formula
C160H252N56O42S • XCF3COOH
Formula Weight
3664.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H]3CCCN3C([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CO)N[H])=O)=O)=O)CC4=CN=CN4)=O)=O)CC5=CN=CN5)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)C)=O)CC6=CNC7=C6C=CC=C7)=O)CC8=CC=C(O)C=C8)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=CC=C9)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C160H252N56O42S.C2HF3O2/c1-14-79(6)121(148(252)198-102(40-27-56-183-160(174)175)152(256)214-57-29-43-114(214)146(250)209-120(78(4)5)147(251)186-71-116(224)191-96(36-23-52-179-156(166)167)131(235)199-103(126(163)230)61-86-31-18-17-19-32-86)208-117(225)72-185-130(234)95(35-22-51-178-155(164)165)193-142(246)110(74-218)206-128(232)82(9)189-137(241)104(62-87-44-46-91(222)47-45-87)201-138(242)105(63-88-68-184-94-34-21-20-33-92(88)94)200-127(231)83(10)190-144(248)112-41-28-58-215(112)153(257)109(66-115(162)223)205-150(254)123(81(8)16-3)211-141(245)108(67-119(228)229)203-145(249)113-42-30-59-216(113)154(258)125(85(12)221)213-135(239)99(39-26-55-182-159(172)173)197-149(253)122(80(7)15-2)210-136(240)100(48-49-118(226)227)195-133(237)101(50-60-259-13)196-143(247)111(75-219)207-140(244)106(64-89-69-176-76-187-89)202-132(236)97(37-24-53-180-157(168)169)194-139(243)107(65-90-70-177-77-188-90)204-151(255)124(84(11)220)212-134(238)98(38-25-54-181-158(170)171)192-129(233)93(161)73-217;3-2(4,5)1(6)7/h17-21,31-34,44-47,68-70,76-85,93,95-114,120-125,184,217-222H,14-16,22-30,35-43,48-67,71-75,161H2,1-13H3,(H2,162,223)(H2,163,230)(H,176,187)(H,177,188)(H,185,234)(H,186,251)(H,189,241)(H,190,248)(H,191,224)(H,192,233)(H,193,246)(H,194,243)(H,195,237)(H,196,247)(H,197,253)(H,198,252)(H,199,235)(H,200,231)(H,201,242)(H,202,236)(H,203,249)(H,204,255)(H,205,254)(H,206,232)(H,207,244)(H,208,225)(H,209,250)(H,210,240)(H,211,245)(H,212,238)(H,213,239)(H,226,227)(H,228,229)(H4,164,165,178)(H4,166,167,179)(H4,168,169,180)(H4,170,171,181)(H4,172,173,182)(H4,174,175,183);(H,6,7)/t79-,80-,81-,82-,83-,84+,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,120-,121-,122-,123-,124-,125-;/m0./s1
InChi Key
OIGNQVVSSBCJHC-ZDHMBUIMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $401

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    Product Description

    Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.1 It is found in the hypothalamus, medulla, and pituitary in rats.2 PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively).2,3 It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM).2,3 PrRP (100 nM) increases the release of gonadotropin-releasing hormone (GnRH; Item No. 24762), vasoactive intestinal peptide (VIP; Item No. 24996), and galanin (Item No. 24456) from rat medial basal hypothalamic explants.4 It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol.4 PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seal, L.G., Small, C.J., Shillo, W.S., et al. PRL-releasing peptide inhibits food intake in male rats via the dorsomedial hypothalamic nucleus and not the paraventricular hypothalamic nucleus. Endocrinology 142(10), 4236-4243 (2001).

    2. Langmead, C.J., Szekeres, P.G., Chambers, J.K., et al. Characterization of the binding of [125I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Br. J. Pharmacol. 131(4), 683-688 (2000).

    3. Engström, M., Brandt, A., Wurster, S., et al. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. J. Pharmacol. Exp. Ther. 305(3), 825-832 (2003).

    4. Seal, L.J., Small, C.J., Kim, M.S., et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology 141(5), 1909-1912 (2000).