A synthetic precursor of angiotensin I
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Angiotensinogen (1-13) (human) (trifluoroacetate salt)

Item No. 24988

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidine, trifluoroacetate salt
Molecular Formula
C79H116N22O17 • XCF3COOH
Formula Weight
1645.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(O)=O)CC2=CN=CN2)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)=O)CC5=CN=CN5)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)CC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C79H116N22O17.C2HF3O2/c1-11-44(9)64(99-71(110)56(30-47-22-24-51(102)25-23-47)94-73(112)62(42(5)6)97-67(106)53(20-16-26-86-79(81)82)90-66(105)52(80)34-61(103)104)75(114)95-58(32-49-36-84-39-88-49)77(116)101-27-17-21-60(101)72(111)93-55(29-46-18-14-13-15-19-46)68(107)92-57(31-48-35-83-38-87-48)69(108)91-54(28-41(3)4)70(109)98-63(43(7)8)74(113)100-65(45(10)12-2)76(115)96-59(78(117)118)33-50-37-85-40-89-50;3-2(4,5)1(6)7/h13-15,18-19,22-25,35-45,52-60,62-65,102H,11-12,16-17,20-21,26-34,80H2,1-10H3,(H,83,87)(H,84,88)(H,85,89)(H,90,105)(H,91,108)(H,92,107)(H,93,111)(H,94,112)(H,95,114)(H,96,115)(H,97,106)(H,98,109)(H,99,110)(H,100,113)(H,103,104)(H,117,118)(H4,81,82,86);(H,6,7)/t44-,45-,52-,53-,54-,55-,56-,57-,58-,59-,60-,62-,63-,64-,65-;/m0./s1
InChi Key
VOZVBIXRBIDKTP-JIWBPDQXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Angiotensinogen (1-13) is a synthetic peptide precursor of angiotensin I (Item No. 24737) that corresponds to amino acids 1-13 of endogenous human angiotensinogen.1 It is cleaved by renin at the Leu-Val peptide bond to release angiotensin I, which is then converted to angiotensin II (Item No. 17150) by angiotensin converting enzyme (ACE) and exerts vasoconstrictive properties. Angiotensinogen (1-13) has been used in the production of anti-angiotensinogen monoclonal antibodies.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tewksbury, D.A., Dart, R.A., and Travis, J. The amino terminal amino acid sequence of human angiotensinogen. Biochem. Biophys. Res. Commun. 99(4), 1311-1315 (1981).

    2. Sawa, H., Kawaguchi, H., Mochizuki, N., et al. Distribution of angiotensinogen in diseased human hearts. Mol. Cell Biochem. 132(1), 15-23 (1994).