An adenosine A2A receptor antagonist
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Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Cancer

CPI-444

Item No. 25024

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(5-methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
CAS Number
1202402-40-1
Synonyms
  • Ciforadenant
Molecular Formula
C20H21N7O3
Formula Weight
407.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
321, 352 nm
SMILES
CC1=CC=C(O1)C2=C3C(N(CC4=CC=CC(CO[C@@H]5COCC5)=N4)N=N3)=NC(N)=N2
InChi Code
InChI=1S/C20H21N7O3/c1-12-5-6-16(30-12)17-18-19(24-20(21)23-17)27(26-25-18)9-13-3-2-4-14(22-13)10-29-15-7-8-28-11-15/h2-6,15H,7-11H2,1H3,(H2,21,23,24)/t15-/m0/s1
InChi Key
KURQKNMKCGYWRJ-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $167

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    10 mg

    $306

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    25 mg

    $702

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    Cayman Chemical
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    Product Description

    CPI-444 is an antagonist of the adenosine A2A receptor.1 It reduces tumor area in mouse model of murine Her2/neu-expressing breast cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scott, B.A., Armstrong, T., and Jaffee, E.M. Inhibition of adenosine A2A receptor (A2AR) by CPI-444 enhances CD8+ T cell killing of a HER-2/neu expressing murine tumor. Cancer Res. 74(14), 320 (2016).