An internal standard for the quantification of L-thyroxine
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Unlabeled Version(s)
14116L-Thyroxine
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L-Thyroxine-13C9,15N

Item No. 25039

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine-carboxy,α,β,1,2,3,4,5,6-13C9-15N
CAS Number
1431868-11-9
Synonyms
  • L-T4-13C9,15N
  • Levothyroxine-13C9,15N
Molecular Formula
C6[13C]9H11I4[15N]O4
Formula Weight
786.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.14 mg/mlDMSO: 2.5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
SMILES
OC1=C(I)C=C(O[13C]2=[13C](I)[13CH]=[13C]([13CH2][13C@H]([15NH2])[13C](O)=O)[13CH]=[13C]2I)C=C1I
InChi Code
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1/i1+1,2+1,3+1,6+1,10+1,11+1,12+1,14+1,15+1,20+1
InChi Key
XUIIKFGFIJCVMT-LPIUGHGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $1,003

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    Product Description

    L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine (Item No. 14116) by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine.1,2,3 In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone (Item No. 22917) from the anterior pituitary in mice.1 It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism.2,3 Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bowers, C.Y., Schally, A.V., Reynolds, G.A., et al. Interactions of L-thyroxine or L-triiodothyronine and thyrotropin-releasing factor on the release and synthesis of thyrotropin from the anterior pituitary gland of mice. Endocrinology 81(4), 741-747 (1967).

    2. Fabris, N., Muzzioli, M., and Mocchegiani, E. Recovery of age-dependent immunological deterioration in Balb/c mice by short-term treatment with L-thyroxine. Mech. Ageing Dev. 18(4), 327-338 (1982).

    3. Fabris, N., and Mocchegiani, E. Endocrine control of thymic serum factor production in young-adult and old mice. Cell Immunol. 91(2), 325-335 (1985).