A flavonoid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Baohuoside I

Item No. 25062

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
CAS Number
113558-15-9
Synonyms
  • Icariin II
  • Icariside II
Molecular Formula
C27H30O10
Formula Weight
514.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
271 nm
SMILES
O=C(C(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)=C(C2=CC=C(OC)C=C2)O3)C4=C3C(C/C=C(C)\C)=C(O)C=C4O
InChi Code
InChI=1S/C27H30O10/c1-12(2)5-10-16-17(28)11-18(29)19-21(31)26(37-27-23(33)22(32)20(30)13(3)35-27)24(36-25(16)19)14-6-8-15(34-4)9-7-14/h5-9,11,13,20,22-23,27-30,32-33H,10H2,1-4H3/t13-,20-,22+,23+,27-/m0/s1
InChi Key
NGMYNFJANBHLKA-LVKFHIPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $135

    Add

    10 mg

    $203

    Add

    25 mg

    $378

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.1,2,3,4,5 It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC50 = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.1,2 Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively).4 It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.3 Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dell'Agli, M., Galli, G.V., Dal Cero, E., et al. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J. Nat. Prod. 71(9), 1513-1517 (2008).

    2. Gao, J., Dang, Y., Yin, C., et al. Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2O2 -induced PC12 cells death by inhibiting mitochondria-mediated autophagy. J. Cell. Mol. Med. 21(2), 375-386 (2017).

    3. Yin, C., Deng, Y., Gao, J., et al. Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats. Neuroscience 328, 69-79 (2016).

    4. Li, S.Y., Teh, B.S., Seow, W.K., et al. Effects of the plant flavonoid baohuoside-1 on cancer cells in vitro. Cancer Lett. 53(2-3), 174-181 (1990).

    5. Zhou, F., Xin, H., Liu, T., et al. Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes. J. Androl. 33(5), 832-844 (2012).