A phenolic acid with diverse biological activities
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Isomer(s)
361891-O-Caffeoylquinic Acid
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Cryptochlorogenic Acid

Item No. 25098

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,3R,4α,5R)-4-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,3,5-trihydroxy-cyclohexanecarboxylic acid
CAS Number
905-99-7
Synonyms
  • 4-O-Caffeoylquinic Acid
Molecular Formula
C16H18O9
Formula Weight
354.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 71 mg/mlDMSO: 50 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 25 mg/ml
λmax
219, 245, 330 nm
SMILES
O=C(O)[C@@]1(O)C[C@@H](O)[C@H](OC(/C=C/C2=CC(O)=C(O)C=C2)=O)[C@H](O)C1
InChi Code
InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1
InChi Key
GYFFKZTYYAFCTR-JUHZACGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    10 mg

    $161

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    50 mg

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    100 mg

    $1,042

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    Cayman Chemical
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    Product Description

    Cryptochlorogenic acid is a phenolic acid that has been found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, and has diverse biological activities.1,2,3,4 It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 11.13 μM).1 Cryptochlorogenic acid inhibits the growth of S. aureus (MIC = 0.5 mg/ml).2 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 5.26 μg/ml).3 Cryptochlorogenic acid is allergenic, inducing degranulation of RBL-2H3 mast cells in vitro and increasing plasma serotonin and β-hexosaminidase levels in guinea pigs in vivo.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, H.A., Islam, N., Kwon, Y.S., et al. Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food Chem. Toxicol. 49(2), 376-384 (2011).

    2. Liang, L., Zhou, Q., Hao, Z., et al. The discovery of antibacterial natural compound based on peptide deformylase. Comb. Chem. High Throughput Screen. 21(4), 292-297 (2018).

    3. Wang, J., Cao, X., Jiang, H., et al. Antioxidant activity of leaf extracts from different Hibiscus sabdariffa accessions and simultaneous determination five major antioxidant compounds by LC-Q-TOF-MS. Molecules 19(12), 21226-21238 (2014).

    4. Wang, F., Li, C., Li, Y., et al. Study on the anaphylactoid of three phenolic acids in honeysuckle. J. Ethnopharmacol. 170, 1-7 (2015).